创伤性脑损伤后认知障碍的MRI研究进展

创伤性脑损伤(traumatic brain injury,TBI)后可有一系列并发症发生,认知障碍是最常见、最持久的并发症之一。目前关于TBI后认知障碍的临床诊断大多停留在应用神经心理学的方法,缺乏认知障碍发生的客观结构改变证据,从而影响了TBI后认知障碍的早期诊断、治疗方案确定及预后评价。近年来,随着影像技术尤其是磁共振成像(magnetic resonance imaging,MRI)新序列的研发,多种新兴、无创MRI新序列可以清晰显示全脑的微细结构并可构建出脑网络结构。笔者通过阅读大量文献总结了各种MRI新技术在评价TBI后认知障碍发生的研究进展。

A review of the application of MRI techniques in cognitive impairment after traumatic brain injury

Traumatic brain injury(TBI) is closely related to a series of complications, among which cognitive impairment is a most common and long-lasting one. Currently, the diagnosis of cognitive impairment after TBI remained mostly by using a neuropsychological method while lacking the evidence of objective brain structure changes, thus affecting the treatment plan and prognosis assessment. In recent years, with the development of new MRI sequence imaging technology, a variety of new MRI sequences can clearly show the micro-structure of the whole brain and brain network. In this review, we mainly summarize the research progress of new MRI sequence in evaluation of cognitive impairment after TBI.