乳腺肿块能量多普勒超声与微血管密度的相关性研究

【目的】探讨能量多普勒超声（power Doppler imaging，PDI）与微血管密度（microvessel density，MVD）检测乳腺肿块血管生成的相关性并评价其临床应用价值。【方法】超声检测乳腺肿块患者55例（其中良性组25例，恶性组30例），采用计算机对肿块能量多普勒血流信号进行定量分析，测定彩色像素密度（color pixel density，CPD）；抗CD34因子免疫组化染色测定肿块MVD，对CPD与MVD的相关性进行分析。【结果】恶性组CPD、MVD较良性组高，两者差异有显著性意义（P〈0．01）。恶性组中腋下淋巴结转移组的CPD及MVD均高于无腋下淋巴结转移组（P〈0．01）。良恶性肿块的CPD与MVD间具有良好相关性（r=0．846，r=0．889，P〈0．01）。【结论】能量多普勒超声所测CPD可较好反应乳腺肿块血流情况，有助于乳腺疾病的鉴别诊断，与微血管密度计数相结合，能全面反映肿瘤血管生成状态。

Correlation between power Doppler ultrasound and microvessel density of breast masses

Objective] To study the correlation between power Doppler imaging and microvessel density （MVD） about breast masses angiogensis and to valuate the clinical application. Methods] Power Doppler ultrasound was performed on 55 patients with breast mass （25 benign, 30 malignant） .Color pixel density （CPD） with computer-assistant of power Doppler flow signal were analyzed. MVD was calculated in surgical specimen after immunohistochemical staining using anti- factor CD34. The correlation between CPD and MVD was analyzed. Results] The CPD and MVD in malignant group was higher than that in benign group （ P 〈 0. 01 ） . Axillary node - positive tumors demonstrated significantly higher CPD and MVD than did axillary node - negative tumors （P〈0.01）, and good correlation was shown between CPD and MVD （r=0.846, r=0.889, P〈0.01） . Conclusions] Power Doppler CPD as a indicator for breast mass angiogenesis is useful for differential diagnosis of breast diseases. Power Doppler imaging quantafive assessement integrated with MVD can observe intratumoral vaseularizafion overall.