| 新的抗肿瘤药7-hy droxy staurosporine(UCN-01)抑制肿瘤浸润和转移 |
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| 引用本文： | 孟庆慧,邵荣光,徐静文,樊赛军.新的抗肿瘤药7-hy droxy staurosporine(UCN-01)抑制肿瘤浸润和转移[J].金属学报,2000,5(4):289-293. |
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| 作者姓名： | 孟庆慧 邵荣光 徐静文 樊赛军 |
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| 作者单位： | 长岛Jewish 医学中心分子肿瘤实验室, 纽约美国 |
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| 摘 要： | 目的和方法 研究7-hydroxystaurosporine(UCN-01)对转移性前列腺肿瘤DU-1 45 细胞浸润和转移的影响。用体外转移和创伤法检查细胞浸润和转移,用Western blotting法检查蛋白质的表达。结果 UCN-01 在非毒性剂量下(100 nmol·L-1)明显地抑制DU-145细胞浸润和转移。而且,UCN-01这种抗肿瘤浸润和转移功能与它增加细胞-细胞粘连分子E-cadherion的表达有关。结论 这些实验首次证实UCN-01 能抑制人前列腺肿瘤细胞的浸润和转移。UCN-01 的临床应用可能更有效地控制前列腺肿瘤转移。
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| 关 键 词： | 7-hydroxystaurosporine(UCN-01) 前列腺 肿瘤 浸润 转移 |
| 收稿时间： | 2000-08-01 |
| 修稿时间： | 2000-10-20 |
Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01), a new ant i-tumor agent |
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| MENG Qing-Hui,SHAO Rong-Guang,XU Jing-Wen,FAN Sai-Jun.Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01), a new ant i-tumor agent[J].Acta Metallurgica Sinica,2000,5(4):289-293. |
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| Authors: | MENG Qing-Hui SHAO Rong-Guang XU Jing-Wen FAN Sai-Jun |
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| Affiliation: | Laboratory of Molecular Oncology, Department of Radiation Oncology ,Long Island Jewish Medical Center, New York;1.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China;2.Division of Rheumatology, Department of Medicine ,The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York, USA |
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| Abstract: | Aim and Methods To investigate the effect of UCN-01(7-hydroxystaurosporine)on cell migration and invasion ability of DU-145, an invasive human pro state cancer cell line.Results It was found that UCN-01 at no n-cytotoxic doses (100 nmol·L-1)significantly inhibited prostate cancer DU-145 cell invasion and migration behaviors.Moreover, this anti-invasion and migration activity of UCN-01 was associated with an up-regulation of cell adhesion molecule E-cadherin.Conclusion These results indicate for first time that UCN-01 inhibits the invasion and migration of human prostate cancer cells.Thus, clinical application of UCN-01 may contribute to the potential benefit for suppression of prostate cancer invasion and metastasis. |
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| Keywords: | 7-hydroxystaurosporine(UCN-0 1) prostate tumor invasion migration |
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