磁共振轴突定向弥散和密度成像技术评估帕金森患者小脑微结构变化

目的探讨利用轴突定向弥散和密度成像(NODDI)对帕金森病患者小脑微结构变化的临床应用价值。方法选择我院35例帕金森病患者且进行NODDI检查的为帕金森病组，选取健康者20例为对照组。根据NODDI扫描结果获取相关参数取向弥散指数（ODI）、细胞内体积分数（VIC）和各向同性隔室的体积分数（VISO）值，分析两组感兴趣区ODI、VIC及VISO值的组间差异，以ROC曲线评估相关参数对帕金森病是否有一定的临床诊断价值。结果帕金森病患者左、右侧齿状核、小脑白质的VIC值，及左、右侧齿状核的ODI值与对照组相比显示减低（P < 0.05），帕金森病患者左、右侧小脑白质的ODI值与对照组相比显示增加（P < 0.05）。ROC曲线显示，齿状核左、右侧VIC诊断帕金森病患者的AUC为0.743、0.767，齿状核左、右侧ODI诊断帕金森病患者的AUC为0.891、0.694。结论NODDI可以反映帕金森病患者小脑微观结构的变化，其参数值可以作为帕金森病患者的评估指标。 

Clinical application of MR Neurite orientation dispersion and density imaging technique to the changes of cerebellar dentate nucleus in patients with Parkinson's disease

ObjectiveTo explore the clinical value of Neurite orientation dispersion and density imaging (NODDI) in cerebellar microstructural changes in patients with Parkinson's disease (PD).MethodsTwenty healthy persons and 35 patients with Parkinson's disease (PD) were selected as case group and control group respectively. According to the relevant parameters of NODDI scanning results, orientation dispersion index (ODI), intracellular volume fraction (VIC) and isotropic volume fraction (VISO) value, ROC curve was used to evaluate whether the related parameters had certain clinical diagnostic value for Parkinson's disease.ResultsThe VIC and ODI values of dentate nucleus, cerebellar white matter and dentate nucleus in PD patients were significantly lower than those in healthy controls (P < 0.05). The ODI values of cerebellar white matter in PD patients were higher than that in the controls (P < 0.05). At the same time, ROC curve showed that the AUC of patients with PD diagnosed by VIC on the left and right side of dentate nucleus were 0.743 and 0.767, and the AUC of patients with PD diagnosed by ODI on the left and right side of dentate nucleus were 0.891 and 0.694, respectively.ConclusionNODDI can reflect the changes of cerebellar microstructure in patients with PD, and its parameters can be used as an evaluation index for patients with PD.