| 紫外分光光度法测定溴吡斯的明片中溴吡斯的明的含量 |
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| 引用本文： | 徐美玲,谭群友,柳珊,张梨,张景.紫外分光光度法测定溴吡斯的明片中溴吡斯的明的含量[J].中国药房,2011(8):743-745. |
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| 作者姓名： | 徐美玲 谭群友 柳珊 张梨 张景 |
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| 作者单位： | 重庆医科大学高校药物工程研究中心和生物化学与分子药理重点实验室;第三军医大学大坪医院野战外科研究所胸外科中心; |
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| 基金项目： | 2009年博士点基金资助项目(20095503120008); 重庆市首批高等学校优秀人才资助项目(KJ090308) |
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| 摘 要： | 目的:建立测定溴吡斯的明片中溴吡斯的明含量的方法。方法:采用紫外分光光度法,以去离子水为空白,在269nm波长处测定溴吡斯的明的含量。结果:溴吡斯的明检测浓度在16.56～41.40μg·mL-(1r=0.9999)范围内与吸光度呈良好的线性关系;平均回收率为99.87%,RSD=0.19%(n=9)。结论:该法操作简便、精密度好、结果可靠,适用于溴吡斯的明片中溴吡斯的明含量的快速测定。
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| 关 键 词： | 紫外分光光度法 溴吡斯的明片 溴吡斯的明 含量测定 |
Content Determination of Pyridostigmine Bromide in Pyridostigmine Bromide Tablets by UV Spectrophotometry |
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| XU Mei-ling,LIU Shan,ZHANG Li,ZHANG Jing-qing TAN Qun-you.Content Determination of Pyridostigmine Bromide in Pyridostigmine Bromide Tablets by UV Spectrophotometry[J].China Pharmacy,2011(8):743-745. |
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| Authors: | XU Mei-ling LIU Shan ZHANG Li ZHANG Jing-qing TAN Qun-you |
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| Affiliation: | XU Mei-ling,LIU Shan,ZHANG Li,ZHANG Jing-qing(Chongqing Medicine Engineering Research Center,Key Laboratory of Biochemical & Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,China) TAN Qun-you(Center of Thoracic Surgery,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China) |
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| Abstract: | OBJECTIVE： To establish the method for the content determination of pyridostigmine bromide in pyridostigmine bromide tablets. METHODS：The contents of pyridostigmine bromide were determined at 269 nm with ionized water as blank con- trol by UV spectrophotometry. RESULTS ：. The linear range of pyridostigmine bromide was 16.56-41.40 μg. mL-1 （r= 0.999 9） with an average recovery of 99.87 % （RSD = 0.19 %, n=9）. CONCLUSION： The method is convenient in operation, precise and reliable for rapid content determination for pyridostigmine bromide tablets. |
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| Keywords: | UV spectrophotometry Pyridostigmine bromide tablets Pyridostigmine bromide Content determination |
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