| 双色ES探针检测慢性粒细胞白血病bcr/abl融合基因的应用研究 |
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| 引用本文： | 杜庆华,林秀梅,应逸,毛平.双色ES探针检测慢性粒细胞白血病bcr/abl融合基因的应用研究[J].广州医学院学报,2006,34(3):50-52. |
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| 作者姓名： | 杜庆华 林秀梅 应逸 毛平 |
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| 作者单位： | 广州医学院附属市一人民医院中心实验室,广州,510180 |
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| 摘 要： | 目的:探讨使用bcr/abl双色ES探针的荧光原位杂交(fluorescence in-situ hybridization,FISH)应用于慢性粒细胞白血病bcr/abl融合基因检测的意义.方法:使用荧光原位杂交方法对2005年1月至2006年2月本院收治的12例慢性粒细胞白血病患者之骨髓细胞进行检测分析.结果:12例CML均检出bcr/abl基因的存在,其中2例伴ASS基因缺失.结论:使用bcr/abl双色ES探针进行荧光原位杂交能为bcr/abl融合基因的检测提供准确直观的依据.
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| 关 键 词： | 慢性粒细胞白血病 荧光原位杂交 bcr/abl融合基因 |
| 文章编号： | 1008-1836(2006)03-0050-03 |
| 收稿时间： | 03 3 2006 12:00AM |
| 修稿时间： | 2006年3月3日 |
Detection of Bcr/Abl Fusion Gene by Dual Color ES Probe in Chronic Myeloid Leukemia |
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| DU Qing-hua,LIN Xiu-mei,YING Yi,MAO Ping.Detection of Bcr/Abl Fusion Gene by Dual Color ES Probe in Chronic Myeloid Leukemia[J].Academic Journal of Guangzhou Medical College,2006,34(3):50-52. |
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| Authors: | DU Qing-hua LIN Xiu-mei YING Yi MAO Ping |
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| Abstract: | Objective:To investigate the use of fluorescence in situ hybridization(FISH) with bcr/abl dual color ES probe in detection of gene subset of chronic myeloid leukemia(CML).Methods: the bcr/abl fusion gene was detected with FISH in bone marrow cells from 12 CML cases.Results: all of 12 CML cases were bcr/abl gene positive by FISH and 2 cases were associated with ASS gene deletion.Conclusion: the use of FISH with bcr/abl dual color ES probe provided accurate molecular diagnosis for CML. |
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| Keywords: | chronic myeloid leukemia FISH bcr/abl fusion gene |
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