遗传性痉挛性截瘫伴薄胼胝体的影像学表现

目的：分析遗传性痉挛性截瘫伴薄胼胝体（HSP-TCC）的影像学特点，以提高对此病的认识。方法：结合文献复习并报告一家族3例HSP-TCC患者的影像学表现。结果：本组3例HSP-TCC患者均显示胼胝体菲薄、颈胸髓明显变细，内见长T2信号、弥漫性非特异性脑白质病变和轻度脑萎缩。结论：HSP-TCC可广泛影响中枢神经系统，MRI特异性表现包括薄胼胝体，侧脑室周围白质长T2信号，脊髓萎缩及信号异常及后期出现轻度到中度脑萎缩。

The imaging characteristics of hereditary spastic paraplegia with thin corpus callosum

Objective： To analyze the imaging characteristics of hereditary spastic paraplegia with thin corpus callosum （HSP-TCC）, so as to get a better understanding of the disease. Methods： Three patients from the same family with HSP-TCC were reported with reviewing of the literature. Results： Thin corpus callosum, long T2 signal in the thinning cervical and thoracic spinal cord were seen. Diffused unspecific white matter lesions with mild brain atrophy, were also seen in the three HSP-TCC cases of this group. Conclusion： The central nervous system may be affected extensively by HSP-TCC, characteristic MRI signs including thin corpus callosum, long T2 signal in the white matter around lateral ventricle and in the spinal cord, atrophy and abnormal signal of the spinal cord, as well as subsequent mild or moderate brain atrophy.