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Cortical circumferential profile of SPECT cerebral perfusion in Alzheimer's disease |
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| Authors: | Gordon J Harris PhD Instructor Jonathan M Links PhD Associate Professor Godfrey D Pearlson MB BS Director Edwaldo E Camargo MD Associate Professor |
| Affiliation: | a Department of Psychiatry, The Johns Hopkins Medical Institutions, Baltimore, MD, USA b Departments of Environmental Health Sciences and Radiology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA c Division of Psychiatric Neuroimaging, The Johns Hopkins Medical Institutions, Baltimore, MD, USA d Department of Psychiatry, The Johns Hopkins Medical Institutions, Baltimore, MD, USA e Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA |
| Abstract: | We developed a semiautomatic method termed “cortical circumferential profiling” for objective analysis of cerebral cortex function in emission tomographic neuroimaging studies. This method treats cortex as a continuous ring near the outer brain edge. A computer algorithm samples the cortex at 60 contiguous, equiangular locations, using 1-cm2 samples. These values are plotted as a function of cortical angle to produce the cortical circumferential profile. This method was used in a study of regional cerebral perfusion in 15 patients with Alzheimer's disease and 8 elderly control subjects using N-isopropyl I-123]-iodoamphetamine. Cortical circumferential profiling decreases variability, examines the entire cortex within slices at preselected levels above the orbital-meatal line, and facilitates intrasubject and intersubject comparisons. |
| Keywords: | Cerebral emission computed tomography semiautomated quantification cortical circumferential profile Alzheimer's disease regional cerebral blood flow |
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