硫氧还蛋白还原酶-2在非小细胞肺癌中的表达及预后

目的:探讨硫氧还蛋白还原酶-2(thioredoxin reductase-2,TrxR2)在非小细胞肺癌(NSCLC)中的表达及对患者预后的影响.方法:免疫组化法检测90例手术后NSCLC癌组织及癌旁正常肺组织中TrxR2的表达,分析TrxR2表达与患者临床病理特征及生存预后的关系.结果:TrxR2在NSCLC组织中的表达高于癌旁正常组织(P＜0.05),TrxR2的表达与患者性别、是否吸烟、肿瘤组织分级、TNM分期无相关性(P＞0.05),而与年龄及淋巴结转移显著相关(P＜0.05).随访90例患者发现TⅨR2高表达组的患者预后更差(P＜0.05).结论:TrxR2在NSCLC中高表达,有望成为NSCLC转移及预后判断的重要指标.

Expression and prognosis of TrxR2 in non-small cell lung cancer

Objective:To investigate the expression and clinical significance of thioredoxin reductase-2 (TrxR2) in non small cell lung cancer (NSCLC).Methods:The expression of TrxR2 in 90 cases of NSCLC was detected by immunohistochemical method,and the survival time was analyzed.Results:The expression of TrxR2 in NSCLC tissues was significantly higher than that in normal tissues,and the difference was statistically significant (P ＜ 0.05).The expression of TrxR2 was not related to gender,smoking index,tumor differentiation and TNM stage (P ＞ 0.05),while was significantly related to age and lymph node metastasis(P ＜0.05).The prognosis of patients with high expression of TrxR2 (P ＜ 0.05) was worse than that of the patients with other expression.Conclusion:TrxR2 is highly expressed in NSCLC and is closely related to age and lymph node metastasis.It is expected to be as an important marker in transfer and prognosis judgement.