阿柔比星A聚乳酸毫微粒主要性质研究

目的：对载药毫微粒主要质量指标载药量、包封率及其关系，粒径及其分布进行研究，方法：以阿柔比星Ａ聚乳酸微粒为研究对象，以分光光度测定载药量与包封率，以激光粒度分析仪测定粒径及其分布。结果：阿柔比星Ａ聚乳酸毫微粒平均载药量为１８．５％。平均包封率为８６．７％，平均数目径为８０ｎｍ，平均体积径为２３０ｎｍ。结论：载药量与包封率之间具有一定关系。体积径分布是载药毫微粒粒径分布评价不可忽视的内容。

Study on main characteristics of aclarubicin A polylactide nanoparticle

A polylactide nanoparticle of aclarubicin A was prepared and the main characteristics such as, the drug loading (DL), the embedding ratio (ER), and relationships between the diameter and the distribution of nanoparticle were investigated. The DL and ER were determined by UV, while the diameter and the distribution were determined by laser mastersizer TM . Results showed that the mean DL and ER were 18.5% and 86.7%; and the mean number diameter and the mean volume diameter were 80 and 230nm respectively. It was concluded that relationships between DL and ER; as well as the volume diameter distribution are important characteristics for the preparation of aclarubicin A polylactide nanoparticle.