| 对溴甲基苯甲酸甲酯的合成研究 |
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| 引用本文： | 资爱平,唐刚,晏彩先,马永翠,王大伟,毕韵梅.对溴甲基苯甲酸甲酯的合成研究[J].广州化工,2012(4):21-23. |
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| 作者姓名： | 资爱平 唐刚 晏彩先 马永翠 王大伟 毕韵梅 |
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| 作者单位： | 云南师范大学化学化工学院 |
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| 基金项目： | 国家自然科学基金(20864003);云南省社会发展科技计划应用基础研究专项面上项目(2009ZC064M) |
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| 摘 要： | 在四氯化碳溶液中,在光照条件下对甲基苯甲酸甲酯与N-溴代丁二酰亚胺(NBS)反应合成对溴甲基苯甲酸甲酯。通过正交实验得到对溴甲基苯甲酸甲酯的最佳合成条件为:NBS用量为对甲基苯甲酸甲酯的1.1倍,反应时间为4 h,过氧化苯甲酰为NBS的0.03倍,四氯化碳为对甲基苯甲酸甲酯的11倍,产率90.5%。
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| 关 键 词： | 对溴甲基苯甲酸甲酯 自由基取代 正交实验 合成 |
Study on Synthesis of Methyl 4-(bromomethyl)benzoate |
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| ZI Ai-ping,TANG Gang,YAN Cai-xian,MA Yong-cui,WANG Da-wei,BI Yun-mei.Study on Synthesis of Methyl 4-(bromomethyl)benzoate[J].GuangZhou Chemical Industry and Technology,2012(4):21-23. |
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| Authors: | ZI Ai-ping TANG Gang YAN Cai-xian MA Yong-cui WANG Da-wei BI Yun-mei |
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| Affiliation: | (College of Chemistry and Chemical Engineering,Yunnan Normal University,Yunnan Kunming 650092,China) |
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| Abstract: | Methyl 4-(bromomethyl)benzoate was synthesized by the reaction of methyl 4-methylbenzoate with N-bromosuccinimide(NBS).The optimum conditions of synthesizing the compound by orthogonal test obtained were that the molar ratio of N-bromosuccinimide to methyl 4-methylbenzoate was 1.1:1,reaction time was 4 h,the molar ratio of benzoyl peroxide to n-bromosuccinimide was 0.03:1,and the molar ratio of carbon tetrachloride to methyl 4-methylbenzoate was 11:1.Under the optimum synthetic conditions,the yield of the product was 90.5%. |
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| Keywords: | methyl 4-(bromomethyl)benzoate free radical substitution reaction orthogonal test synthesis |
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