一种新型大鼠腹部心脏移植模型应用体会

目的：建立一种更加方便、稳定的大鼠异位心脏移植模型。方法：以Wistar大鼠为供体，SD大鼠为受体，将供心的主动脉和肺动脉分别与受体肾血管上方的主动脉和左肾静脉用连续缝合技术行端侧吻合。术后受体和移植心存活≥3d视为手术成功。同期建立改良Ono模型与之比较。姑果。新术式组完成异位心脏移植40例，改良Ono术式组完成异位心脏移植20例，成功率分别为92．5％和75％。两组间缺血时间、手术时间比较具有显著差异（P〈0．01）。新术式组并发症的发生率较改良Ono术式组明显降低。结论：新术式方便、可靠，并发症与死亡率较低，是一种理想的大鼠异位心脏移植模型。

Experence of A New Abdominal Cardiac Transplantation Model in Rats

Objective:To establish an improved heterotopic cardiac transplantation model in rats. Methods:Sprague Dawley rats have been used as recipients and Wistar rats as donors. Donor aorta was anastomosed to the recipient's suprarenal abdominal aorta;donor pulmonary artery was anastomosed to the left renal vein of the recipient using continuous suture technique The operation was considered be successful if the recipient rat and graft survive over 3 days. They were compared with models performed using modified Ono procedure Results: Forty rats of heterotopic cardiac transplantation were performed using new procedure and twenty were performed using modified Ono procedure, with successful rate 92. 5% and 75% respectively. Mean time of ischemia and operation was both significantly shorter in rats using new procedure than that of rats using modified Ono procedure The rate of complications in rats using new procedure was significantly lower. Conclusion:The method is easy,quick and reliable, which has a low incidence of morbidity and mortality. The model perhaps is more suitable for heterotopic heart transplantatioa