| 病毒性脑炎患儿血清及脑脊液中基质金属蛋白酶-9及其抑制剂的变化及临床意义 |
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| 引用本文： | 朱崇峰,曹亚芹,郭秋芬,苏怡凡,董皎,罗英媚,邱潇,柳慧.病毒性脑炎患儿血清及脑脊液中基质金属蛋白酶-9及其抑制剂的变化及临床意义[J].中国实用神经疾病杂志,2009,12(17):10-12. |
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| 作者姓名： | 朱崇峰 曹亚芹 郭秋芬 苏怡凡 董皎 罗英媚 邱潇 柳慧 |
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| 作者单位： | 1. 河南周口市中心医院儿科,周口,466000
2. 甘肃省人民医院儿科,兰州,730000 |
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| 摘 要： | 目的 探讨病毒性脑炎患儿血清和脑脊液中基质金属蛋白酶-9(MMP-9)和基质金属蛋白酶组织抑制剂-1(TIMP-1)水平的变化及临床意义.方法 采用酶联免疫吸附试验(ELISA)检测48例病毒性脑炎患儿和25例正常患儿血清和脑脊液中MMP-9、TIMP-1水平.结果 病毒性脑炎患儿轻型组和重型组血清和脑脊液中基质金属蛋白酶-1和基质金属蛋白酶组织因子-1及其二者比值均明显高于对照组(P＜0.05或0.01),且重型组较轻型组明显增高(P＜0.05).结论 检测病毒性脑炎患儿血清和脑脊液中MMP-9、TIMP-1水平及MMP-9/TIMP-1比例对指导临床诊断和治疗具有一定的意义.
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| 关 键 词： | 病毒性脑炎 基质金属蛋白酶-9 基质金属蛋白酶组织抑制剂-1 |
Clinical significance and changes of cerebrospinal fluid and serum matrix metalloproteinase-9 and matrix metalloproteinase inhibitors in children with viral encephalitis |
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| Zhu Chongfeng,Cao Yaqin,Guo Qiufen,et al..Clinical significance and changes of cerebrospinal fluid and serum matrix metalloproteinase-9 and matrix metalloproteinase inhibitors in children with viral encephalitis[J].Chinese Journal of Practical Neruous Diseases,2009,12(17):10-12. |
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| Authors: | Zhu Chongfeng Cao Yaqin Guo Qiufen |
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| Affiliation: | Zhu Chongfeng,Cao Yaqin,Guo Qiufen,et al.Department of Pediatris,Zhoukou City Central Hospital,Zhoukou 466000,China |
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| Abstract: | Objective To discuss the clinical significance and changes of cerebrospinal fluid and serum matrix metalloproteinase-9(MMP-9) and tissue inhibtor of metalloproteinase-1(TIMP-1) in children with viral encephalitis.Methods Enzyme-linked immunosorbent assay(ELISA) was adopted for detecting serum and cerebrospinal fluid of MMP-9,TIMP-1 level in 48 cases of children with viral encephalitis and 25 cases of healthy children.Results Serum and cerebrospinal fluid matrix metalloproteinase-1 and tissue inhibitor of me... |
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| Keywords: | Viral encephalitis Matrix metalloproteinase-9 Tissue inhibitor of metalloproteinase-1 |
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