子宫腺肌病子宫内膜-肌层连接区超微结构研究

目的研究子宫腺肌病子宫内膜-肌层连接区超微结构的改变与子宫腺肌病发病的关系。方法透射电镜下观察子宫腺肌病组子宫内膜-肌层连接区(8例)和对照组子宫内膜-肌层连接区(8例)的超微结构。结果与对照组相比,子宫腺肌病组腺上皮细胞表面微绒毛密集,胞质内线粒体体积增大,功能活跃,未见细胞凋亡;平滑肌细胞排列紊乱,正常带结构扭曲,胞质内细胞器减少,线粒体空泡化;肥大细胞增多,胞质内充满大量电子密度高的颗粒,周围胶原纤维增多,与平滑肌细胞紧密相邻。结论子宫内膜-肌层连接区的结构改变与子宫腺肌病的发生有密切关系。

The ultra-structure of endometrial-myometrial junction in adenomyosis

Objective To study the uhrastructural change in endometrial-myometrial junction associated with adenomyosis. Methods The ultrastructure of endometrial-myometrial junction from 8 patients with adenomyosis and 8 healthy controls was studied using transmission electron microscope. Results Compared with controls, glandular epithelium in adenomyosis presented with dense microvilli on the surface, enlarged and actively functioning mitochondria, but no apoptosis; smooth muscle cells showed irregular alignments, distorted bands, fewer organelles, more mast cells, vacuolated mitochondria, widespread electron-dense particles in the cytoplasm, more surrounding collagen fibers in close adjacency. Conclusion Distorted constitution of endometril-myometrial junction is related to adenomyosis.