| 灯盏花素纳米脂质体包封率测定方法研究 |
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| 引用本文： | 熊非,朱家壁,王维,华小兵.灯盏花素纳米脂质体包封率测定方法研究[J].药学学报,2004,39(9):755-757. |
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| 作者姓名： | 熊非 朱家壁 王维 华小兵 |
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| 作者单位： | 中国药科大学,药物制剂研究所,江苏,南京,210009 |
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| 摘 要： | 灯盏花素(breviscapine)是菊科植物短葶飞蓬(Erigeron breviscapus(vant.)Hand-Mazz)中提取的黄酮类有效成分。临床多用于治疗脑梗死、脑血栓、脑出血等。将药物制成脂质体,能帮助药物进入脑部,提高治疗指数。灯盏花素水溶性较差,直接溶于注射用水有一定困难,将其制成脂质体可以解决其难溶问题,提高药物稳定性及载药量,同时提高药物的靶向性及疗效。包封率是脂质体质量评定的重要指标,本实验建立了灯盏花素纳米脂质体包封率的测定方法,该法操作简单、可行、准确性较好。
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| 关 键 词： | 灯盏花素 纳米脂质体 包封率 反透析法 |
| 收稿时间： | 2003-09-03 |
Determination of entrapment efficiency of breviscapine nanoliposomes |
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| XIONG Fei,ZHU Jia-bi,WANG Wei,HUA Xiao-bing.Determination of entrapment efficiency of breviscapine nanoliposomes[J].Acta Pharmaceutica Sinica,2004,39(9):755-757. |
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| Authors: | XIONG Fei ZHU Jia-bi WANG Wei HUA Xiao-bing |
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| Affiliation: | Institute of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. |
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| Abstract: | AIM: To determine the entrapment efficiency of breviscapine nanoliposomes. METHODS: Retrodialysis method was used to determine the entrapment efficiency of breviscapine nanoliposomes. The drug recovery and the sample recovery were considered to verify the feasibility of the method. RESULTS: The drug recovery was (99.6 +/- 0.6)%. The sample recovery was (99.9 +/- 0.8)%. The entrapment efficiency of breviscapine nanoliposomes was (75.3 +/- 2.3)%. CONCLUSION: The method used in this study is simple, applicable and accurate for determination of the entrapment efficiency of breviscapine nanoliposomes. |
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| Keywords: | breviscapine nanoliposome entrapment efficiency retrodialysis |
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