| 注射用顺铂细菌内毒素检查法的建立 |
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| 引用本文： | 邓子煜,邢蓉,张大萍.注射用顺铂细菌内毒素检查法的建立[J].蚌埠医学院学报,2002,27(6):543-544. |
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| 作者姓名： | 邓子煜 邢蓉 张大萍 |
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| 作者单位： | 蚌埠医学院附属医院药剂科,安徽,蚌埠,233004 |
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| 摘 要： | 目的:建立注射用顺铂的细菌内毒素检查法.方法:参照中国药典2000年版检测细菌内毒素的凝胶法.结果:以氯化钠注射液溶解的注射用顺铂经细菌内毒素检查用水稀释4倍后对鲎试剂无干扰作用.结论:用灵敏度为0.5 Eu/ml的鲎试剂检测注射用顺铂的细菌内毒素是可行的,可以用细菌内毒素法取代家兔热原法.
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| 关 键 词： | 顺铂 细菌内毒素 干扰试验 凝胶法 |
| 文章编号： | 1000-2200(2002)06-0543-02 |
| 修稿时间： | 2001年12月31日 |
Bacterial endotoxin test of cisplatin for injection |
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| DENG Zi yu,XING Rong,ZHANG Da ping.Bacterial endotoxin test of cisplatin for injection[J].Journal of Bengbu Medical College,2002,27(6):543-544. |
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| Authors: | DENG Zi yu XING Rong ZHANG Da ping |
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| Abstract: | Objective:To establish a method for detection of bacterial endotoxin in cisplatin for injection.Methods:Gel clot technique introduced in the chinese pharmacopoeia 2000 edition was consulted.Results:The cisplatin for injection when dissolved by sodium chloride injection with 4 times of water had no interference influence on tachypleus amebocyte lysate(TAL) in detecting bacterial endotoxin.Conclusions:It is feasible to test the bacterial endotoxin in the cisplatin for injection by TAL having a sensitivity of 0.5 Eu/ml,which can act as an alternative for the rabbit pyrogen test. |
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| Keywords: | cisplatin bacterial endotoxin interference experiment gel clot technique |
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