| 川芎嗪衍生物liguzinediol对戊巴比妥钠致急性心力衰竭大鼠血流动力学的影响 |
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| 引用本文： | 郭瑶,周静,卞慧敏,朱青,李伟,吴艳.川芎嗪衍生物liguzinediol对戊巴比妥钠致急性心力衰竭大鼠血流动力学的影响[J].中国实验方剂学杂志,2012,18(6):170-174. |
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| 作者姓名： | 郭瑶 周静 卞慧敏 朱青 李伟 吴艳 |
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| 作者单位： | 南京中医药大学,南京 210029;江苏省中药药效与安全性评价重点实验室,南京210029 |
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| 基金项目： | 国家自然科学基金项目(81072542);"十一五"科技重大专项(2009ZX09103-081);江苏省自然科学基金资助项目(BK2011077);江苏省高校优势学科建设工程项目 |
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| 摘 要： | 目的:观察liguzinediol(2,5-二羟甲基-3,6-二甲基吡嗪)对戊巴比妥钠致急性心力衰竭大鼠血流动力学的影响.方法:40只雄性SD大鼠右侧股静脉恒速注射戊巴比妥钠制备急性心衰模型,造模后随机分为5组:模型组(给予NS),阳性对照组(地高辛,22.5 μg· kg -1),liguzinediol(5,10,20 mg·kg-1)3个剂量组,每组8只,稳定后经恒速注射泵右侧股静脉单次给药,多道生理记录仪记录全过程中大鼠血流动力学指标的变化.结果:静脉给药后,liguzinediol 3个剂量组均使大鼠左心室收缩压(LVSP)、左心室内压力最大上升速度(+dp/dtmax)、左心室内压力最大下降速度(- dp/dtmax)、收缩压(SAP)、舒张压(DAP)在1min内开始显著增加,并且对心率影响不大,心肌收缩力增强.结论:liguzinediol对急性心衰大鼠心脏具有正性肌力作用.
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| 关 键 词： | liguzinediol 急性心力衰竭 戊巴比妥钠 血流动力学 |
| 收稿时间： | 2011/11/23 0:00:00 |
The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital |
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| GUO Yao,ZHOU Jing,BIAN Hui-min,ZHU Qing,LI Wei and WU Yan.The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital[J].China Journal of Experimental Traditional Medical Formulae,2012,18(6):170-174. |
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| Authors: | GUO Yao ZHOU Jing BIAN Hui-min ZHU Qing LI Wei and WU Yan |
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| Affiliation: | Nanjing University of Chinese Medicine, Nanjing 210029, China; Clinical Pharmacology of Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing University of Chinese Medicine, Nanjing 210029, China; Clinical Pharmacology of Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing University of Chinese Medicine, Nanjing 210029, China; Clinical Pharmacology of Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing University of Chinese Medicine, Nanjing 210029, China; Clinical Pharmacology of Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing University of Chinese Medicine, Nanjing 210029, China; Clinical Pharmacology of Nanjing University of Chinese Medicine, Nanjing 210029, China;Nanjing University of Chinese Medicine, Nanjing 210029, China; Clinical Pharmacology of Nanjing University of Chinese Medicine, Nanjing 210029, China |
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| Abstract: | Objective:To investigate the effect of liguzinediol on the hemodynamics in acute heart failure rats.Method:Forth rats were intravenously injected pentobarbital through a micro-infusion pump and randomly divided into 5 groups:saline control group(NS),positive control group(digoxin,22.5 μg·kg-1),three doses of liguzinediol groups(liguzinediol 5,10,20 mg·kg-1).The heart contractile founctions such as left ventricular systolic pressure(LVSP),maximal rising and falling rate of ventricular pressure(±dp/dtmax),systolic arterial pressure(SAP),diastolic arterial pressure(DAP),heart rate(HR) were measured using a RM6240B/C four channel physiological recording instrument.Result:Liguzinediol induced significant increases of LVSP,+dp/dtmax,-dp/dtmax,and SAP.Conclusion:Liguzinediol induces a positive inotropic effect on the heart in acute heart failure rats. |
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| Keywords: | liguzinediol acute heart failure pentobarbital haemodynamics |
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