高尔基体蛋白73与甲胎蛋白对肝癌诊断价值的研究

目的：探讨甲胎蛋白（AFP）与高尔基体蛋白73（GP73）对肝癌早期诊断的价值。方法采用酶联免疫法（Enzyme linked immunosorbent assay，ELISA）对肝癌患者80例、肝硬化患者30例血清中AFP、GP73进行检测，30例健康体检者作为对照。结果①肝癌组、肝硬化组、正常对照组AFP平均浓度为64.5μg/L、50.1μg/L、21.9μg/L （肝癌组vs对照组P〈0.01，肝硬化组vs对照组P〈0.01，肝硬化组vs肝癌组P〈0.01），肝癌组、肝硬化组、正常对照组GP73平均浓度为268.4μg/L、192.3μg/L、49.8μg/L （P〈0.01）。②AFP诊断肝癌的ROC曲线下面积为0.729，P=0.000，GP73诊断肝癌的ROC曲线下面积为0.892，P=0.000。AFP联合GP73对肝癌诊断的ROC曲线下面积为0.902。结论 GP73诊断肝癌的价值高于AFP，AFP＋GP73联合检测不能提高诊断效率。

Diagnostic value of Golgi protein 73 and AFP protein in patients with hepatocellular carcinoma ZOU Tong-hui,WANG Yong-qiang,ZOU Jun

Objective To explore the value of alpha-fetoprotein （AFP） and Golgi protein 73 （GP73） in the early diagnosis of hepatocellular carcinoma. Methods AFP and GP73 were detected with enzyme-linked immunosor-bent assay （enzyme linked immunosorbent assay, ELISA） in 80 patients with hepatocellular carcinoma and 30 patients with hepatocirrhosis. 30 healthy subjects were selected as controls. Results ①The mean concentrations of AFP in hepatocellular carcinoma group, hepatocirrhosis group and control group was 64.5, 50.1, and 21.9 respectively, among which there were significantly differences （P〈0.01）. The concentrations of GP73 in hepatocellular carcinoma group, hepatocirrhosis group and control group was 268.4, 192.3 and 49.8 respectively, among which there were significantly differences （P〈0.01）.②The areas under ROC curves of AFP and GP73 were 0.729 and 0.892 respectively in diagno-sis of hepatocellular carcinoma. The area under ROC curve of AFP combined GP73 was 0.902 for diagnosis of hepato-cellular carcinoma. Conclusion Compared with AFP, GP73 is more sensitive and accurate in diagnosis of liver can-cer, and it is not necessary to test GP73 combined with AFP.