微量元素硒对弥漫性毒性甲状腺肿的影响及其护理探讨

目的：观察微量元素硒对弥漫性毒性甲状腺肿的影响，并探讨其护理方法及效果。方法选取2010年11月至2013年1月于本院进行治疗的90例弥漫性毒性甲状腺肿患者为研究对象，将90例根据随机分为对照组（常规治疗组）45例和观察组（常规治疗加硒治疗组）45例，两组患者均针对治疗方式与疾病情况进行个性化护理干预，然后将两组中单纯性突眼及浸润性突眼者的治疗总有效率及治疗前后的促甲状腺素受体抗体（TRAB）、抗甲状腺过氧化物酶抗体（TPOAB）及白介素6（IL-6）的血清含量与阳性率进行比较。结果观察组中单纯性突眼及浸润性突眼者的治疗总有效率分别为96.67%和93.33%，其均高于对照组，治疗后3个月与6个月时的TRAB、TPOAB及IL-6的血清含量分别为（5.10±0.69） U/L、（3.29±0.52） U/L、（68.59±6.24） U/ml、（50.33±4.68） U/ml及（21.86±3.65） pg/ml、（15.25±3.20） pg/ml，阳性率分别为24.44%、11.11%、35.56%、15.56%及26.67%、11.11%，其均低于对照组与治疗前的检测结果，差异均有统计学意义（P〈0.05），且两组患者均对护理干预效果满意。结论微量元素硒在弥漫性毒性甲状腺肿应用效果较好，同时给予患者积极的护理更有利于疾病的治疗。

Investigation on the influence of trace element selenium on the patients with diffuse toxic goiter and its nursing.

Objective To observe the influence of trace element selenium on the patients with diffuse toxic goiter, and study the nursing method and effect. Methods Ninety patients with diffuse toxic goiter in our hospital from November 2010 to January 2013 were selected and randomly divided into control group （conventional therapy group） with 45 cases and observation group （conventional therapy and selenium treatment group） with 45 cases. The two groups were taken care according to the treatment and disease state, then the total effective rates of simple exoph-thalmos and infiltrative exophthalmos, the serum content and positive rate of thyrotropin receptor antibody （TRAB）, anti-thyroid peroxidase antibody （TPOAB）, and interleukin 6 （IL-6） before and after the treatment in two groups were compared. Results The total effective rates of simple exophthalmos and infiltrative exophthalmos in the observa-tion group were 96.67%and 93.33%respectively,which were higher than those in the control group. The serum con-tent of TRAB, TPOAB, and IL-6 at third and sixth month after treatment were （5.10 ± 0.69） U/L, （3.29 ± 0.52） U/L, （68.59 ± 6.24） U/ml, （50.33 ± 4.68） U/ml, （21.86 ± 3.65） pg/ml, and （15.25 ± 3.20） pg/ml respectively,with the positive rates of 24.44%,11.11%, 35.56%, 15.56%, 26.67%and 11.11%respectively, which were lower than those in the con-trol group or before the treatment （P〈0.05）. Patients in both groups were all satisfied with the nursing effect and atti-tude. Conclusion The trace element selenium positive affected the patients with diffuse toxic goiter, and they also benefited from the positive nursing.