鼻咽癌组织中CCR7和CXCR4的表达及其临床意义

目的探讨CXC族趋化因子受体4（CXCR4）和CC族趋化因子受体7（CCR7）在鼻咽癌（NPC）组织中的表达及其临床意义。方法随机选择2012年1月至2013年10月本院NPC患者60例,取其鼻咽癌组织（病例组）,选择同期鼻咽部炎症患者30例,取其鼻咽部组织（对照组）,采用免疫组织化学检测两组患者的CXCR4和CCR7表达情况。结果病例组CCR7和CXCR4的阳性表达分别为32例和27例,均高于对照组的6例和4例,其差异均有统计学意义（P〈0.05）,Ⅲ期＋Ⅳ期患者的CCR7和CXCR4阳性例数为22例和16例,高于Ⅰ期＋Ⅱ期的10例和11例,其差异均具有统计学意义（P〈0.05）;M1期CCR7阳性例数为24例,高于M0期的8例,差异也具有统计学意义（P〈0.05）;有淋巴结转移的患者CCR7和CXCR4阳性例数分别为23例和24例,未转移者9例和3例,其差异也具有统计学意义（P〈0.05）。结论 CCR7和CXCR4在鼻咽癌中的阳性表达率均明显高于非鼻咽癌组织,且与鼻咽癌临床分期和淋巴结转移有关,CXCR4和CCR7在鼻咽癌的发生和发展中具有重要的意义。

Expressions and clinical significance of CXCR4 and CCR7 in nasopharyngeal carcinoma

Objective To explore the expression of CXC chemokine receptor-4（CXCR4） and CC chemokine receptor-7（CCR7） in nasopharyngeal carcinoma（NPC） and its clinical significance. Methods Sixty patients with NPC admitted in our hospital from January 2012 to October 2013 were randomly selected for NPC tissue,which was assigned as the disease group. Another 30 cases with nasopharyngeal inflammation were selected as control group for normal nasopharyngeal tissue. CXCR4 and CCR7 in two groups were detected with expression by immunohistochemistry. Results The positive expression cases of CCR7 and CXCR4 in the disease group were 32cases and 27 cases respectively, which were higher than those in the control group with 6 cases and 4 cases, and there were statistically significant different（P〈0.05）. The positive expression of CCR7 and CXCR4 in Ⅲ stage andⅣ stage were 22 cases and 16 cases, which were higher than those in Ⅰ stage and Ⅱ stage with 10 cases and 11 cases, and the difference has statistical significance（P〈0.05）. The positive expression of CCR7 in M1stage was 24,which was higher than that in M0stage with 8 cases, and the difference was statistically significant（P〈0.05）. The positive expression of CCR7 and CXCR4 in patients with lymph node metastasis were 23 cases and 24 cases, which were higher than in patients without metastasis with 9 and 3 cases, and the difference was statistically significant（P〈0.05）. Conclusion The positive expressions of CCR7 and CXCR4 in patients with NPC were significantly higher than those in non-carcinoma tissue. It is related with clinical stage and lymph node metastasis. CXCR4 and CCR7play important roles in the occurrence and development of nasopharyngeal carcinoma.