强迫症和精神分裂症患者的听及视信息加工过程中感觉性脑诱发电位特征比较

背景应用脑诱发电位技术比较强迫症和精神分裂症患者在听及视信息加工过程中感觉性脑诱发电位特征,是否可发现一些异常的生物学指标.目的观察强迫症和精神分裂症患者感觉性脑诱发电位长潜伏期及听觉脑诱发电位的变化特征,并与健康人相比较.设计随机抽样法,病例对照研究.地点和对象病例组为宁波市康宁医院门诊和住院患者,对照组均为身心健康的志愿者.干预利用意大利百胜公司GalileoSirius电生理仪对36例强迫症和36例精神分裂症患者用33例正常对照组进行了短声、闪光刺激,完成听觉脑诱发电位、视觉脑诱发电位.主要观察指标观察主波出现率,各波的波幅和潜伏期.结果发现与正常对照组相比,强迫症和精神分裂症患者无论在听觉诱发电位(auditory evoked potentials AEP),还是在视觉诱发电位(vi-sual evoked potentials VEP)中,其P3波出现率明显减少(x2=12.73,P＜0.01;x2=13.13,P＜0.01);其中VEP/P3出现率精神分裂症与强迫症相比更为减少(x2=34.62,P＜0.01).强迫症和精神分裂症患者的AEP/P2波呈双峰率现象均增高(x2=4.17,P＜0.05).强迫症、精神分裂症和正常对照组三组在相比,在AEP中潜伏期N1、P2波延长(F=6.95,P＜0.01;F=6.45,P＜0.01),波幅N1波下降(F=3.55,P＜0.05);VEP中P2潜伏期延长(F=6.16,P＜0.01),波幅P2,P3波均有改变(F=7.96,P＜0.01;F=12.06,P＜001).结论强迫症和精神分裂症患者在听、视信息加工过程均有不同程度的异常,以精神分裂症为重,其异常指标与其发病机制和症状有关,值得关注.

Comparison of sensory evoked potential during the auditory and visual information processing procedure between patients with obsessive-compulsive disorder and schizophrenia

BACKGROUND: Whether the application of cerebral evoked potential technique in the comparison of the sensory evoked potential during the auditory and visual information processing procedure between patients with obsessive-compulsive disorder and schizophrenia could discover any abnormal biological indices or not?OBJECTIVE: To observe the long latency of the sensory evoked potential and the variation of auditory evoked potential in patients with obsessive-compulsive disorder, which would be compared with that of normal individuals as well.DESIGN: A randomised case-controlled trial.SETTING and PARTICIPANTS: Patients of the outpatient and inpatient departments of Ningbo Kangning Hospital were selected in case group and healthy volunteers were selected in control group.INTERVENTIONS: Short tone and flash stimulation were conducted by GalileoSirius electrophysiology analyser made by Baisheng Company(Italy)in 36 patients with obsessive-compulsive disorder, 36 schizophrenes and 33normal individuals for the detection of auditory evoked potential and visual evoked potential.MAIN OUTCOME MEASURES: The detective rate of main wave, the amplitude and latency of each wave were observed.RESULTS: Compared with normal control group, in the auditory evoked potentials and visual evoked potentials of the patients with obsessive-compulsive disorder and schizophrenia, the detective rate of P3 wave significantly reduced(x2 = 12.73, P ＜ 0.01; x2 = 13.13, P ＜ 0.01 ). The detective rate of P3 in visual evoked potential of schizophrene was even less than that of patients with obsessive-compulsive disorder(x2 = 34.62, P＜ 0.01). The double peak P2 wave in auditory evoked potential increased in both patients (x2 =4. 17, P ＜ 0.05) . The comparisons among obsessive-compulsive disorder group, schizophrenia group and control group indicated that the N1latency and P2 wave prolonged in auditory evoked potential( F = 6.95, P ＜0.01; F = 6.45, P＜0.01 ) and N1 amplitude decreased( F = 55, P ＜0.05); P2 latency in visual evoked potential prolonged( F = 6. 16, P ＜0.01), and the amplitudes of P2 and P3 changed( F = 7.96, P ＜0.01;F= 12.06, P＜0.01).CONCLUSION: Patients of obsessive-compulsive disorder and schizophrenia have abnormities of different extent in the auditory and visual information processing procedure. Schizophrenes have more serious abnormities.