心肌活力颗粒治疗气虚血瘀型扩张型心肌病伴心力衰竭临床研究

目的心肌活力颗粒对气虚血瘀型扩张型心肌病伴心力衰竭患者的影响。方法将120例气虚血瘀型扩张型心肌病伴心力衰竭患者随机分为2组,对照组60例予西医常规治疗,治疗组60例在对照组治疗基础上加心肌活力颗粒。2组均1个月为1个疗程,共治疗1个疗程。统计治疗前后心悸、气短、气喘、胸闷(痛)、烦躁不安、咳嗽及自汗证候,心胸比例,左室舒张末内径及左室射血分数(LVEF)变化情况,统计心功能疗效及中医证候疗效,并进行安全性评价。结果 2组治疗后各中医证候积分及总分与本组治疗前比较均明显下降(P<0.01),且治疗组心悸、气短、气喘、胸闷(痛)、烦躁不安证候积分及总分低于对照组(P<0.01)。2组治疗后心胸比例与本组治疗前比较均明显下降(P<0.05),左室舒张末内径缩小(P<0.05),LVEF增加(P<0.05),且组间比较差异有统计学意义(P<0.05),治疗组改善优于对照组。2组心功能疗效、中医证候疗效总有效率分别为70.0%、96.7%,对照组分别为50.0%、55.0%,治疗组均优于对照组(P<0.05)。2组均无明显不良反应。结论心肌活力颗粒可明显改善气虚血瘀型扩张型心肌病患者心功能及临床症状、体征,且无明显毒副作用。

Clinical research of Xinjihuoli granule on the treatment of Qi deficiency to blood stasis type dilated cardiomyopathy with cardiac failure

Objective To assess the influence of Xinjihuoli granule on the treatment of Qi deficiency to blood stasis type dilated cardiomyopathy with cardiac failure. Methods 120 cases of Qi deficiency to blood stasis type dilated cardiomyopathy with cardiac failure were randomly divided into two groups. 60 cases in control group were given conventional western medicine therapy. 60 patients in treatment group were treated by combination of Xin- jihuoli granule and basis of control group treatment. The course was a month in two groups. The changes palpitations,shortness of breath, wheezing, chest tightness （pain）, irritability, cough and spontaneous syndromes, cardiothoracic ratio, left ventricular end diastolic diameter and left ventricular ejection fraction （LVEF） were recorded. Cardiac function efficacy and effect of traditional Chinese medicine syndromes, and safety evaluation were completed. Results Traditional Chinese medicine syndrome points and total score after treatment were significantly decreased as com- pared with those before treatment in two groups （P 〈 O. O1 ）. Palpitations, shortness of breath, wheezing, chest tight- ness （ pain）, irritability syndrome score and total score in treatment group were lower than those in control group be- fore treatment （P 〈 O. O1 ）. After treatment, cardiothoracic ratio compared with this group before treatment were sig- nificantly decreased （ P 〈 O. 05 ）, left ventricular end diastolic diameter narrowing （ P 〈 0.05 ） and LVEF increased （P 〈 0.05）, and there was statistically significant between groups （P 〈 O. 05 ）, the treatment group was better than the control group. Efficacy of cardiac function, total effective rate of traditional Chinese medicine syndromes in treat- ment group （70.0%, 96.7% ） was higher than those in control group （50.0%, 55.0%, P 〈 0.05 ）. Conclusion Xinjihuoli granule can significantly improve cardiac function and clinical symptoms and signs of Qi deficiency toblood stasis type dilated cardiomyopathy and no obvious side effects.