Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins |
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Authors: | Email author" target="_blank">Marie?Kune?ováEmail author Vojtěch?Hainer Eva?Tvrzická Stephen?D?Phinney Vladimír??tich Jana?Pa?ízková Ale??Zák Albert?J?Stunkard |
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Affiliation: | (1) Fourth Medical Department, Charles University, Prague;(2) Galileo Laboratories, 95054 Santa Clara, California;(3) Third Medical School, Charles University, Prague, Czech Republic;(4) Department of Psychiatry, University of Pennsylvania, 19104 Philadelphia, Pennsylvania;(5) Obesity Management Centre, Third Medical Department, First Medical School, Charles University, U nemocnice 1, 128 08 Prague, Czech Republic |
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Abstract: | Fourteen pairs of obese female monozygotic twins were recruited for a study of genetic influences on serum and adipose fatty
acid (FA) composition. Following 1 wk of inpatient stabilization, fasting serum and adipose tissue obtained by surgical excision
were analyzed by thin-layer and gas chromatography. Intrapair resemblances (IPR) for individual FA were assessed by Spearman
rank correlation and by analysis of variance and were found in serum cholesteryl esters (CE), triglycerides (TG), and adipose
TG. With two exceptions (CE linoleate and adipose eicosapentaenoate), these IPR were limited to the nonessential FA. Palmitate
had significant IPR in four lipid fractions; in serum CE and adipose TG palmitate was strongly correlated with multiple measures
of adiposity. In contrast to other lipid fractions, serum phosphatidylcholine (PC) FA had 12 IPR, of which 6 were essential
FA including arachidonate (r=0.76, P<0.0005), eicosapentaenoate (r=0.78, P<0.0005), and docosahexaenoate (r=0.86, P<0.0001). The PC IPR could not be explained by analysis of preadmission 7-d food records. After dividing the pairs into two
groups differing and nondiffering according to fat intake of individuals in the pair, there was no evidence of a gene-environment
interaction between fat intake and FA composition. The IPR for nonessential FA indicate that there is active genetic control
of either food choices or postabsorptive metabolic processing. The high level of IPR in the PC fraction in contrast to the
other lipid fractions suggests strong genetic influence over selection of specific FA for this membrane fraction independent
of diet. |
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