| 大八角枝叶中1个新的seco-prezizaane型倍半萜化合物 |
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| 引用本文： | 方振峰,张丽,刘欣,张涛.大八角枝叶中1个新的seco-prezizaane型倍半萜化合物[J].中草药,2016,47(16):2803-2805. |
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| 作者姓名： | 方振峰 张丽 刘欣 张涛 |
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| 作者单位： | 江汉大学医学院 药学系, 湖北 武汉 430056;江汉大学医学院 药学系, 湖北 武汉 430056;江汉大学医学院 药学系, 湖北 武汉 430056;江汉大学医学院 药学系, 湖北 武汉 430056 |
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| 基金项目： | 江汉大学科研启动经费资助项目（0600034） |
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| 摘 要： | 目的研究大八角Illicius majus枝叶的化学成分。方法采用硅胶、Sephadex LH-20柱色谱、快速制备色谱和制备HPLC等技术进行分离和纯化,通过HR-ESI-MS、1D-NMR、2D-NMR等波谱数据鉴定化合物的结构。通过MTT法评价了化合物的细胞毒活性。结果从大八角枝叶提取物中分离得到1个seco-prezizaane型倍半萜,命名为大八角酮(1)。化合物1对人结肠癌细胞HCT-8、人肝癌细胞Bel-7402、人胃癌细胞BGC-823以及人肺癌细胞A549的IC50值分别为42.3、48.5、51.1和39.9μmol/L。结论化合物1为1个新的倍半萜类化合物,未表现出明显的细胞毒活性。
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| 关 键 词： | 八角属 大八角 倍半萜 seco-prezizaane型 大八角酮 细胞毒活性 |
| 收稿时间： | 2016/2/24 0:00:00 |
A new seco-prezizaane-type sesquiterpenoid from twigs and leaves of Illicium majus |
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| FANG Zhen-feng,ZHANG Li,LIU Xin and ZHANG Tao.A new seco-prezizaane-type sesquiterpenoid from twigs and leaves of Illicium majus[J].Chinese Traditional and Herbal Drugs,2016,47(16):2803-2805. |
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| Authors: | FANG Zhen-feng ZHANG Li LIU Xin and ZHANG Tao |
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| Affiliation: | Department of Pharmacy, School of Medicine, Jianghan University, Wuhan 430056, China;Department of Pharmacy, School of Medicine, Jianghan University, Wuhan 430056, China;Department of Pharmacy, School of Medicine, Jianghan University, Wuhan 430056, China;Department of Pharmacy, School of Medicine, Jianghan University, Wuhan 430056, China |
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| Abstract: | Objective To study the chemical constituents from the twigs and leaves of Illicius majus. Methods The compound was isolated by column chromatography over silica gel, Sephadex HL-20, and flash chromatography coupled with preparative HPLC. The structure was elucidated by spectroscopic analysis including HR-ESI-MS, 1D-NMR, and 2D-NMR. The cytotoxic activities were assessed by MTT. Results A new seco-prezizaane-type sesquiterpenoid named majusatone (1) was isolated from the twigs and leaves of I. majus. Compound 1 exhibited the cytotoxic activity against HCT-8, Bel-7402, BGC-823, and A549 with IC50 values of 42.3, 48.5, 51.1, and 39.9 mmol/L, respectively. Conclusion Compound 1 is a new special seco-prezizaane-type sesquiterpenoid, and shows no significant cytotoxic activities against HCT-8, Bel-7402, BGC-823, and A549. |
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| Keywords: | Illicium Linn Illicium majus Hook f et Thoms sesquiterpenoid seco-prezizaane-type majusatone cytotoxic activities |
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