多花黄精地上部分化学成分的研究

目的研究多花黄精Polygonatum cyrtonema地上部分的化学成分。方法采用色谱分离技术进行分离和纯化,并根据波谱学数据鉴定化合物的结构。结果从多花黄精地上部分的甲醇提取物中分离得到15个化合物,分别鉴定为(3R)-5,7-dihydroxy-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one(1)、5,7-dihydroxy-6-methyl-3-(2',4'-dihydroxybenzyl)-chroman-4-one(2)、5,7-dihydroxy-6-methyl-3-(4'-hydroxybenzyl)-chroman-4-one(3)、(3S)-3,7-dihydroxy-8-methoxy-3-(3',4'-methylenedioxybenzyl)-chroman-4-one(4)、芹菜素(5)、山柰酚(6)、香草酸(7)、反式对羟基桂皮酸(8)、反式对羟基桂皮酸甲酯(9)、水杨酸(10)、(+)-丁香脂酸(11)、balanophonin B(12)、咖啡酸(13)、苯丙氨酸(14)和松柏醛(15)。结论化合物1、2、7、11、14和15为首次从多花黄精中分离得到,化合物3、4和12为首次从黄精属植物中分离得到。

Chemical constituents from aerial part of Polygonatum cyrtonema

Objective To study the chemical constituents from the aerial part of Polygonatum cyrtonema. Methods The compounds were isolated and purified by means of chromatographic techniques and their structures were identified on the basis of spectral features. Results Fifteen known compounds were isolated in methanol extract from the aerial part of P. cyrtonema and their structures were identified as (3R)-5,7-dihydroxy-3-(2''-hydroxy-4''-methoxybenzyl)-chroman-4-one (1), 5,7-dihydroxy-6-methyl-3-(2'',4''-dihydroxybenzyl)-chroman-4-one (2), 5,7-dihydroxy-6-methyl-3-(4''-hydroxybenzyl)-chroman-4-one (3), (3S)-3,7-dihydroxy-8-methoxy-3-(3'',4''-methylenedioxybenzyl)-chroman-4-one (4), apigenin (5), kaempferol (6), vanillic acid (7), trans-p-hydroxycinnamic acid (8), trans-p-hydroxycinnamic acid methyl ester (9), saliylic acid (10), (+)-syringaresinol (11), balanophonin B (12), caffeic acid (13), phenylalanine (14), and coniferaldehyde (15). Conclusion Compounds 1, 2, 7, 11, 14, and 15 are firstly obtained from P. cyrtonema. Compounds 3, 4, and 12 are isolated from the plants of Polygonatum Mill. for the first time.