健康人纤溶活性与年龄、性别、体重、血脂及吸烟习惯的相关性

对１０４名健康人血浆组织型纤溶酶原激活物（ｔＰＡ）和１３１名健康人血浆纤溶酶原激活物抑制物１（ＰＡＩ１）活性与年龄、性别、体重、血脂及吸烟习惯的关系进行了分析。结果表明：ＰＡＩ１活性随年龄及体重指数增加而增加；男性ＰＡＩ１与年龄、体重呈正相关；女性ＰＡＩ１与ＬＤＬ呈正相关；吸烟组ＰＡＩ１／ｔＰＡ值高于不吸烟组。提示年龄、体重、血脂参与调节纤溶活性，吸烟降低纤溶功能

Relationship of age, sex, body weight, smoking, blood lipids and fibrinolytic activities in healthy subjects

Relationship of plasma activities of tissue type plasminogen activator (tPA) and plasminogen activator inhibitor 1(PAI 1) with age, sex, body weight, smoking, blood lipids were studied in 131 healthy subjects. The results demonstrated that plasma PAI 1 activity increased with age and body weight. PAI 1/t PA ratio was higher in smoking than in non smoking subjects. With multivariate analyses, plasma PAI 1 activity was positively correlated with age, body weight index(BMI) in males, and positively correlated with low density lipoprotein cholesterol(LDL) in females, and negatively correlated with plasma tPA activity. Plasma triglyceride, high density lipoprotein cholesterol did not show a correlation to PAI 1 or tPA activity. It is indicated that age, BMI, blood lipids may contribute to moderate fibrinolytic activities and that smoking may affect fibrinolytic function.