| 清开灵对脑组织谷氨酸含量及NMDA受体的影响 |
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| 引用本文： | 岳少杰,陈检芳,陶永光.清开灵对脑组织谷氨酸含量及NMDA受体的影响[J].中南大学学报(医学版),2000,25(3):213-215. |
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| 作者姓名： | 岳少杰 陈检芳 陶永光 |
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| 作者单位： | |
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| 基金项目： | 国家自然科学基金资助!(39700193) |
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| 摘 要： | 观察清开灵对脑组织中谷氨酸 (Glu)和γ 氨基丁酸 (GABA)含量及NMDA受体的数目、亲和力的影响。结果发现 ,清开灵对脑组织中Glu ,GABA含量及Glu GABA值无明显影响 (P >0 .0 5 ) ;能明显下调神经细胞膜上NMDA受体的数目 (P <0 .0 5 )。提示清开灵的脑保护机制与下调NMDA受体的数目有关
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| 关 键 词： | 清开灵 谷氨酸 γ-氨基丁酸 NMDA受体 MK801 大鼠 |
Effect of QingKaiLing on glutamate and NMDA receptor of brain tissue |
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| YUE Shaojie,CHEN Jiangfang,TAO Yongguang,et al.Effect of QingKaiLing on glutamate and NMDA receptor of brain tissue[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2000,25(3):213-215. |
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| Authors: | YUE Shaojie CHEN Jiangfang TAO Yongguang |
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| Affiliation: | Department of Pediatrics, Xiangya Hospital, Hunan Medical University(Changsha 410008) |
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| Abstract: | The effects of QingKaiLing on the content of glutamate(Glu) and γaminobutyric acid(GABA), and the numbers and affinity of NmethylDaspartate(NMDA) receptor in brain tissue were observed. QingKaiLing did not change the content of Glu and GABA and the ratio of Glu/GABA in brain tissue(P>0.05). The numbers of NMDA receptor on membrane of neuron were significantly decreased in QingKaiLing group(P<0.05). These results suggested that the brain protective mechanism of QingKaiLing be in relation to decreasing the numbers of NMDA receptor. |
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| Keywords: | QingKaiLing glutamate GABA NMDA receptor MK-801 Rats |
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