UV‐ and thermally triggered ring‐opening metathesis polymerization for the spatially resolved functionalization of polymeric monolithic devices |
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Authors: | Claudia Ernst Christian Elsner Andrea Prager Bettina Scheibitz Michael R Buchmeiser |
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Affiliation: | 1. Leibniz‐Institut für Oberfl?chenmodifizierung e.V. (IOM), Permoserstra?e 15, D‐04318 Leipzig, Germany;2. Lehrstuhl für Makromolekulare Stoffe und Faserchemie, Institut für Polymerchemie, Universit?t Stuttgart, Pfaffenwaldring 55, D‐70550 Stuttgart, Germany;3. Institut für Textilchemie und Chemiefasern, K?rschtalstr. 26, D‐73770 Denkendorf, Germany |
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Abstract: | Porous polymeric monolithic supports were prepared via electron beam‐triggered free radical polymerization using a mixture of ethyl methacrylate and trimethylolpropane triacrylate in 2‐propanol, 1‐dodecanol and toluene. Bicyclo2.2.1]hept‐5‐en‐2‐ylmethyl acrylate (1) was grafted onto these monolithic supports in a spatially resolved way with the aid of masks using both electron beam‐ (EB) and UV‐triggered free radical polymerization. The thus immobilized norborn‐2‐ene‐containing graft polymers were further treated with the 2nd‐generation Grubbs initiator, i.e., RuCl2(PCy3)(IMesH2)(CHPh) (4) (IMesH2 = 1,3‐dimesitylimidazolin‐2‐ylidene), and then reacted with bicyclo2.2.1]hept‐5‐en‐2‐ylmethyl pyrene‐1‐carboxylate (2). Alternatively, monoliths completely grafted with poly‐ 1 were surface grafted with 2 in a spatially resolved way in the presence of a latent, UV‐triggerable precatalyst, i.e., Ru(IMesH2)(CF3COO)(t‐BuCN)4+ CF3COO?] (5). Finally, to demonstrate the utility of this chemistry, a 2nd‐generation Grubbs initiator‐based approach was used to prepare a trypsin‐functionalized monolith‐containing chip device that allowed for the online digestion of N‐α‐benzoyl‐L ‐argininethylester hydrochloride. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 |
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Keywords: | monoliths ring‐opening metathesis polymerization ruthenium surface grafting UV |
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