| 阿片肽链中L-苯丙氨酸的保护全合成及表征 |
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| 引用本文： | 马燕,王朝阳.阿片肽链中L-苯丙氨酸的保护全合成及表征[J].精细与专用化学品,2010,18(1):31-33,37. |
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| 作者姓名： | 马燕 王朝阳 |
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| 作者单位： | 1. 西南科技大学生命科学与工程学院,四川,绵阳,620010
2. 四川成都爱斯特医药技术有限公司,四川,成都,611130 |
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| 摘 要： | L-苯丙氨酸经硝化、酯化、叔丁氧羰基(Boc)保护α-氨基、Pd/C还原对位硝基、对甲磺酰氯(MSC1)保护对位氨基、经水解反应后,在酸性条件下脱去叔丁氧羰基(Boc)基团,碱性条件下引入9-芴甲氧羰酰琥珀酰亚胺(Fmocosu),最终生成标题化合物,并且对所合成标题化合物进行了HNMR结构确证。
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| 关 键 词： | L-苯丙氨酸 芴甲氧羰酰琥珀酰亚胺（Fmoc- osu） 对甲磺酰氯（MSCI） 合成 保护 |
Total synthesis and characterization of L-phenylanine of opioid peptides |
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| MA Yan,WANG Zhao-yang.Total synthesis and characterization of L-phenylanine of opioid peptides[J].Fine and Specialty Chemicals,2010,18(1):31-33,37. |
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| Authors: | MA Yan WANG Zhao-yang |
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| Affiliation: | 1.College of Life Science and Engineering/a>;Southwest University of Science and Technology/a>;Mianyang 621010/a>;China/a>;2.AsataTech Pharmaceutical Company limited Chengdu 611130/a>;China |
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| Abstract: | The title compound was synthesized from L-phenylalanine via nitration,esterification,the amino of L-phenylalanine was protected using base-liable Boc group,the reduction of para-nitryl was completed by Pd/ C,the para-amino group was protected using methylsufonyl chloride,after via saponification,Boc was removed in acid condition,and Fmoc-osu could introduce Fmoc group in basic condition,finally the target compound was obtained,the structure was confirmed by ~1HNMR spectra. |
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| Keywords: | L-phenylalamine Fmoc-osu MSCI synthesis protection |
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