Threshold dose–response in radiation carcinogenesis: an approach from chronic β-irradiation experiments and a review of non-tumour doses |
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Authors: | H Tanooka |
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Affiliation: | Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, and Central Research Institute of Electric Power Industry, Komae, Tokyo 201-0004, Japan |
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Abstract: | Purpose : To discuss the threshold dose problem in radiation carcinogenesis after a review of the present author's experimental data on mouse tumour induction by chronic β -irradiation and other relevant data. Conclusions : A threshold dose-response in radiation carcinogenesis appears in certain tissues and under certain conditions. The optimum condition for demonstrating an apparent threshold is with partial-body chronic or repeated radiation rather than with acute whole-body radiation. Its possible mechanism is host tolerance, involving DNA repair, apoptosis and an immune response activated by low radiation doses. This tolerance level was examined by a survey in the literature of non-tumour-inducing doses, D nt, the highest dose at which no significant increase of tumours was observed above the control level. |
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Keywords: | DNA double-strand breaks split-dose recovery potentially lethal damage sublethal damage |
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