| 瓜子金发酵总皂苷的抗炎镇痛活性 |
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| 引用本文： | 朱婷,刘明星,郭申娥,李小莉,王贤文.瓜子金发酵总皂苷的抗炎镇痛活性[J].中国医院药学杂志,2011(12). |
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| 作者姓名： | 朱婷 刘明星 郭申娥 李小莉 王贤文 |
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| 作者单位： | 湖北工业大学生物工程学院; |
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| 摘 要： | 目的:研究瓜子金发酵液中所含总皂苷的抗炎镇痛活性。方法:提取瓜子金发酵液中的总皂苷,采用二甲苯诱导小鼠耳廓肿胀试验模型和腹腔毛细血管通透性试验观察抗炎作用;采用小鼠扭体和热板试验观察镇痛作用;采用最大耐受剂量法进行急性毒性试验,观察小鼠出现的毒性反应和剂量毒性效应的关系。结果:瓜子金发酵总皂苷对二甲苯致小鼠耳廓肿胀、冰醋酸致腹腔毛细血管通透性增高均有明显的抑制作用;能减少冰醋酸刺激致痛小鼠的扭体次数及提高热板致痛小鼠的痛阈值;小鼠灌胃最大耐受剂量13.3g.kg-1,相当于临床用量的100倍。结论:瓜子金发酵总皂苷具有显著的抗炎、镇痛作用,且毒性较低。
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| 关 键 词： | 瓜子金 发酵 总皂苷 抗炎 镇痛 |
Study on the anti-inflammatory and analgesic effect of total saponin from fermented Polygala japonica Houtt. |
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| ZHU Ting,LIU Ming-xing,GUO Shen-e,LI Xiao-li,WANG Xian-wen.Study on the anti-inflammatory and analgesic effect of total saponin from fermented Polygala japonica Houtt.[J].Chinese Journal of Hospital Pharmacy,2011(12). |
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| Authors: | ZHU Ting LIU Ming-xing GUO Shen-e LI Xiao-li WANG Xian-wen |
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| Affiliation: | ZHU Ting,LIU Ming-xing,GUO Shen-e,LI Xiao-li,WANG Xian-wen(Bioengineering College of Hubei University of Technology,Hubei Wuhan 430068,China) |
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| Abstract: | OBJECTIVE To study on the anti-inflammatory and analgesic effect of total saponin from fermented Polygala japonica Houtt.METHODS Total saponins was extracted from fermented Polygala japonica HOUTT.Models of anti-inflammatory reaction were studied by dimethyl benzene induced ear edema and celiac capillary's permeability experiments.Writhing test and hot-plate were used to study the analgesic effects.The maximum tolerated dose method was used to observe the toxic reaction and dose toxic effect relationship.RE... |
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| Keywords: | Polygala japonica Houtt fermentation extracts of total saponin anti-inflammatory activity analgesic activity |
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