| 羧甲基壳聚糖对D-半乳糖诱导氧化损伤模型小鼠肝、脑的保护作用 |
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| 引用本文： | 付青姐,李明春,李强.羧甲基壳聚糖对D-半乳糖诱导氧化损伤模型小鼠肝、脑的保护作用[J].中国医院药学杂志,2011(18). |
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| 作者姓名： | 付青姐 李明春 李强 |
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| 作者单位： | 中国人民解放军第401医院药剂科; |
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| 基金项目： | 全军“十一五”资助项目(编号:06MA09) |
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| 摘 要： | 目的:探索羧甲基壳聚糖(CMC)对D-半乳糖诱导氧化损伤模型小鼠肝、脑的作用。方法:实验分为4组:对照组、CMC组、D-半乳糖模型组、D-半乳糖+CMC组。测定各组小鼠肝、脑超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的活性、丙二醛(MDA)的含量及蛋白质羰基化程度。结果:D-半乳糖可诱导小鼠蛋白质羰基化,诱导小鼠氧化损伤,CMC可使小鼠蛋白质羰基化含量降低,SOD、CAT活性增加,MDA含量降低。结论:CMC对D-半乳糖引起的氧化损伤有一定的保护作用。
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| 关 键 词： | D-半乳糖 羧甲基壳聚糖 氧化损伤 蛋白质羰基化 超氧化物歧化酶 过氧化氢酶 丙二醛 |
Protective effect of carboxymethyl chitosan(CMC) on the liver and brain in mice damaged by D-galactose |
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| FU Qing-jie,LI Ming-chun,LI Qiang.Protective effect of carboxymethyl chitosan(CMC) on the liver and brain in mice damaged by D-galactose[J].Chinese Journal of Hospital Pharmacy,2011(18). |
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| Authors: | FU Qing-jie LI Ming-chun LI Qiang |
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| Affiliation: | FU Qing-jie,LI Ming-chun,LI Qiang (401th Hospital of PLA,Shandong Qingdao 266071,China) |
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| Abstract: | OBJECTIVE To investigate the protective effect of CMC on the liver and brain in mice damaged by D-galactose. METHODS Animals were divided into four groups: control group;D-galactose treated animals;control+CMC group;D-galactose+CMC group.Protein carbonyl and SOD,CAT,MDA of the liver and brain were detected. RESULTS D-galactose induced protein carbonyl of brain and liver,CMC decreased it.CMC increased the activity of SOD and CAT and decreased the MDA content. CONCLUSION CMC might play a protective effect on ... |
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| Keywords: | D-galactose CMC oxidative damage protein carbonyl SOD CAT MDA |
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