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| 大麻素受体1介导的突触可塑性在神经病理性疼痛及其所致抑郁中的作用 | |
| 引用本文： | 潘薇,王星明,张广芬,杨建军.大麻素受体1介导的突触可塑性在神经病理性疼痛及其所致抑郁中的作用[J].中南大学学报(医学版),2017,42(3):340-345. |
| 作者姓名： | 潘薇 王星明 张广芬 杨建军 |
| 作者单位： | 1. 南京大学医学院附属金陵医院/南京军区南京总医院麻醉科，南京 210002；2. 东南大学附属中大医院麻醉科， 南京 210009 |
| 基金项目： | 国家自然科学基金(81503053，81571083)。 |
| 摘 要： | 神经病理性疼痛是一类由躯体感觉系统损伤或疾病导致的以自发痛、痛觉过敏和痛觉超敏为特征的疼
痛，目前认为中枢敏化是神经病理性疼痛产生和维持的关键机制之一。内源性大麻素系统的大麻素受体1可调控神经
递质的释放，改变突触可塑性，进而抑制中枢敏化，可减轻神经病理性疼痛。此外，大麻素受体1激活亦可缓解神经
病理性疼痛所致的抑郁。 |
| 关 键 词： | 大麻素受体1 神经病理性疼痛 抑郁 突触可塑性 |
Role of cannabinoid receptor 1-mediated synaptic plasticity#br# in neuropathic pain and associated depression |
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| PAN Wei,WANG Xingming,ZHANG Guangfen,YANG Jianjun.Role of cannabinoid receptor 1-mediated synaptic plasticity#br# in neuropathic pain and associated depression[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2017,42(3):340-345. | |
| Authors: | PAN Wei WANG Xingming ZHANG Guangfen YANG Jianjun |
| Affiliation: | 1. Department of Anethesiology, Jinling Hospital, Medical School of Nanjing University/Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002; 2. Department of Anethesiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China |
| Abstract: | Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain, allodynia, and hyperalgesia. It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain. Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission, regulates synaptic plasticity, inhibits central sensitization, and thus attenuates neuropathic pain. Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression. |
| Keywords: | cannabinoid receptor 1 neuropathic pain depression synaptic plasticity |
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