Alkylation of Pyrimidine Derivatives with Chloroacetic Acid Esters |
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| Authors: | Krivonogov V P Kozlova G G Belaya E A Spirikhin L V Abdrakhmanov I B |
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| Affiliation: | (1) Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, Russia;(2) Bashkir State Agrarian University, Ufa, Bashkortostan, Russia |
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| Abstract: | Alkylation of 6-methyluracil, 5-hydroxy-6-methyluracil, and 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-ylammonium sulfate with isopropyl and ethyl chloroacetates afforded previously unknown alkyl 2-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetates, alkyl 2-(1-alkoxycarbonylmethyl-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)acetates, 1,3-bis(alkoxycarbonylmethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-ylammonium sulfates, and alkyl 2-1,3-bis(alkoxycarbonylmethyl)-6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yloxy]acetates. |
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