运用实验室数据建立中山地区孕妇TSH的参考区间

目的运用实验室信息管理系统中存储的数据建立符合中山地区孕妇促甲状腺激素(TSH)的参考区间。方法收集2013年1月至2018年12月就诊于中山市博爱医院产科门诊,常规产检孕妇的基本信息及TSH项目的检测结果,共纳入14866例孕妇。所有结果均由DXI800全自动化学发光免疫分析仪检测。将所收集的数据按照孕周不同分为孕早期(1~12周)、孕中期(13~27周)、孕晚期(28~40周),并运用Hoffmann法建立符合该地区孕妇TSH指标的参考区间。结果本研究运用Hoffmann法建立了孕妇TSH检测项目的参考区间,孕早期为0.134~2.233 mIU/L,孕中期为0.278~2.283 mIU/L,孕晚期为0.307~3.329 mIU/L,与目前所运用的美国甲状腺协会(ATA)指南所提供的参考区间存在一定的差异。结论通过运用Hoffmann法,依据该地区的孕妇人群建立了TSH的参考区间,对未来其他实验室依据各地区人群建立符合各地区实验室的不同检测项目的参考区间提供了一定的价值。

Establishing reference intervals of TSH in pregnant women by analysis of laboratory-stored data in Zhongshan area

Objective To establish reference intervals for thyrotropin(TSH)consistent with pregnant women in the region using data stored in the laboratory information management system.Methods From January 2013 to December 2018,14866 pregnant women were enrolled in the obstetric clinic of Bo′ai Hospital of Zhongshan City.The basic information and TSH test results of pregnant women were collected.All the results were detected by DXI800.According to the different gestational weeks,the data collected were divided into three groups:early pregnancy(1-12 weeks),mid pregnancy(13-27 weeks)and late pregnancy(28-40 weeks).The reference interval of TSH index was established by Hoffmann method.Results In this study,Hoffmann method was used to establish the reference interval of TSH test items for pregnant women,which was 0.134-2.233 mIU/L in the early pregnancy,0.278-2.283 mIU/L in the middle pregnancy,0.307-3.329 mIU/L in the late pregnancy,which was different from the reference interval provided by the current ATA guidelines.Conclusion By using Hoffmann method,the reference range of TSH was established according to the pregnant women in this area,which will provide certain value for other laboratories to establish the reference range of different testing items according to the people in each area in the future.