消渴降糖方联合吡格列酮二甲双胍片对2型糖尿病患者的影响

目的:探讨消渴降糖方联合吡格列酮二甲双胍片治疗2型糖尿病患者的治疗效果。方法:98例2型糖尿病患者随机分为观察组(48例,消渴降糖方联合吡格列酮二甲双胍片)和对照组(48例,给予吡格列酮二甲双胍片治疗)。统计分析治疗前后的体重指数,空腹血糖(FBG),餐后2 h血糖(2 h PG),糖化血红蛋白(Hb A1c),低密度脂蛋白(LDL),高密度脂蛋白(HDL),甘油三酯(TG),全血黏度(高切、中切、低切),血浆黏度,纤维蛋白原以及临床疗效与中医症状。结果:两组患者经3个月疗程后,观察组治疗显效数(42/48,87.5%)显著多于对照组(32/48,66.7%),P<0.05。两组患者的体重指数(BMI),FBG,2 h PG,Hb A1c,TG,纤维蛋白原,全血黏度(高切、中切),血浆黏度均低于治疗前(P<0.05),但观察组的FBG(6.42±1.14)VS(6.89±1.02)mmol·L-1],2 h PG(9.12±1.53)VS(9.79±1.68)mmol·L-1],Hb A1c(6.22±1.51)%VS(6.89±1.73)%],TG(4.09±1.12)VS(4.93±1.31)mmol·L-1],纤维蛋白原(2.26±0.94)VS(3.26±1.05)g·L-1],全血黏度高切(4.01±1.17)VS(4.73±1.51)]m Pa·s,中切(5.47±2.08)VS(6.84±2.30)]m Pa·s,低切(8.29±3.07)VS(10.83±3.26)]m Pa·s,血浆黏度(1.24±0.37)VS(1.82±0.62)]m Pa·s改善好于对照组(P<0.05)。治疗后观察组的中医症状记分显著低于对照组(P<0.01)。结论:消渴降糖方联合吡格列酮二甲双胍片治疗2型糖尿病有效改善血糖,其疗效明显。

Therapeutic Effect of Xiaoke Jiangtang Fang Combined with Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets on Patients with Type 2 Diabetes

Objective: To evaluate the therapeutic effect of Xiaoke Jiangtang Fang combined with pioglitazone hydrochloride and metformin hydrochloride tablets on patients with type 2 diabetes. Method: Ninty-eight patients with type 2 diabetes were randomly divided into observation group (48 cases, Xiaoke Jiangtang Fang plus pioglitazone hydrochloride and metformin hydrochloride tablets) and control group (48 cases, pioglitazone hydrochloride and metformin hydrochloride tablets). The body mass index (BMI), fasting blood glucose (FBG), 2 hour postprandial blood glucose (2 hPG), hemoglobin A1c (HbA1c), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG), high/midst/low shear rate of blood viscosity, plasma viscosity, fibrinogen, the clinical symptom, and Chinese medical symptom were calculated and compared. Result: After 3 courses of treatment, the effective rate of observer group (42/48, 87.5%) was significantly higher than control group (32/48, 66.7%) (P<0.05). After treatment, the BMI, FBG, 2 hPG, HbA1c,TG, fibrinogen, high/midst/low shear rate of blood viscosity, and plasma viscosity in two groups were significant decreaseded (P<0.05). However, the FBG (6.42±1.14) VS (6.89±1.02) mmol·L^-1], 2 hPG (9.12±1.53) VS (9.79±1.68)mmol·L^-1], HbA1c(6.22±1.51)% VS (6.89±1.73)%], TG(4.09±1.12) VS (4.93±1.31)mmol·L^-1], fibrinogen(2.26±0.94) VS(3.26±1.05) g·L^-1], high (4.01±1.17) VS (4.73±1.51)mPa·s/midst (5.47±2.08) VS (6.84±2.30) mPa·s/low (8.29±3.07) VS (10.83±3.26) mPa·s shear rate of blood viscosity, and plasma viscosity (1.24±0.37) VS (1.82±0.62) mPa·s in observation group were significant lower than those of control group (P<0.05). The score of traditional Chinese medicine symptom in observer group was significant lower than that of control group after treatment (P<0.01). Conclusion: Xiaoke Jiangtang Fang combined with pioglitazone hydrochloride and metformin hydrochloride tablets have an obviously curative effect on patients with type 2 diabetes.