| 精氨酸加压素对实验性神经细胞老化过程中细胞周期和细胞总蛋白的影响 |
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| 引用本文： | 孙晓江,蔡琰,苏敏,王 ,朱华,陆钦池,邓锦波,张毅.精氨酸加压素对实验性神经细胞老化过程中细胞周期和细胞总蛋白的影响[J].中国病理生理杂志,1996(2). |
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| 作者姓名： | 孙晓江 蔡琰 苏敏 王 朱华 陆钦池 邓锦波 张毅 |
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| 作者单位： | 上海第二医科大学附属仁济医院神经生物学实验室，河北省承德医学院附属医院神经生物学实验室 |
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| 基金项目： | 上海高等院校科学发展基金，河北省自然科学基金 |
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| 摘 要： | 采用小鼠神经母细胞瘤细胞无血清培养，建立神经细胞老化实验研究模型。以流式细胞光度术观察精氨酸加压素（ＡＶＰ）对老化过程中实验性神经细胞的细胞周期和细胞总蛋白的影响。结果发现ＡＶＰ可产生延缓细胞老化的细胞周期和细胞总蛋白的变化。提示ＡＶＰ通过使细胞周期、ＤＮＡ和细胞总蛋白等发生变化来发挥其延缓实验性神经细胞老化的作用。
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| 关 键 词： | 精氨酸加压素，细胞周期，流动血细胞计数 |
Effects of arginine-vasopression on cell cycle and total cellular protein during neuronal aging |
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| Sun Xiao-Jiang, Cai Yan, Su Min, Wang Jun,Zhu Hua, Lu Qin-Chi, Deng Jin-Bo, Zhang Yi.Effects of arginine-vasopression on cell cycle and total cellular protein during neuronal aging[J].Chinese Journal of Pathophysiology,1996(2). |
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| Authors: | Sun Xiao-Jiang Cai Yan Su Min Wang Jun Zhu Hua Lu Qin-Chi Deng Jin-Bo Zhang Yi |
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| Abstract: | Culture of serum-free mouse netiroblastoma cells was used as an experimental modelfor the neuronal aging studies.Nlow cytometry o f cell cycle,DNA and total eellular protein wasused as the indices of neuronal aging.Mfter arginine-vasopressin (AVP) was added into the cul-ture medium,the following general tendencies were obtained:AVP produced effects on cell cycle,DNA and total eellular protein in the direction of delaying neuronal aging.The interrelationshipbetween AVP and neuronal aging needs further investgation. |
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