| 增产菊胺酯对雄性小鼠生殖激素的影响 |
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| 引用本文： | 毛新良,宋瑞琨.增产菊胺酯对雄性小鼠生殖激素的影响[J].应用预防医学,1997,3(2):65-67. |
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| 作者姓名： | 毛新良 宋瑞琨 |
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| 作者单位： | 同济医科大学公共卫生学院 |
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| 基金项目： | 国家“八五”重点科技攻关资助 |
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| 摘 要： | 为了探讨增产菊胺酯引起小鼠精了生成障碍的可能机理，本文研究了增产菊胺酯对雄性小鼠卵泡刺激素（ＦＳＨ）、黄体生成素（ＬＨ）及睾酮（Ｔ）的影响。小鼠经口染毒，隔天一次，连续１０次，第３５天处死。检验因清ＦＳＨ、ＬＨ没有明显变化，而睾丸组织睾酮含量出现剂理依赖性降低，高剂量组与对照组比较有显著性差异（Ｐ〈０．０５），结果表明，增产菊胺酯不影响ＦＳＨ、ＬＨ，而影响Ｔ的合成和分泌。这可能是增产菊胺酯对小鼠精
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| 关 键 词： | 增产菊胺酯 生殖激素 雄性 卫生毒理 |
Effects of Bachmedesh on germ hormone in male mice. |
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| Mao Xinliang,Song Ruikun,Shi Nian.Effects of Bachmedesh on germ hormone in male mice.[J].Journal of Applied Preventive Medicine,1997,3(2):65-67. |
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| Authors: | Mao Xinliang Song Ruikun Shi Nian |
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| Affiliation: | Mao Xinliang,Song Ruikun,Shi Nian. Department of Environmental Toxicology,Tongji Medical University |
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| Abstract: | This paper is to measure follicle stimulating hormone , luteinizing hormone and testosteronc in male mice in order to investigate the possible mechanism of Bachmedesh's toxicity on spermatogenesis. Bashmedesh was orally ad- ministrated to mice, every other day for 10 times. On the 35th day, FSH and LH within serum showed no dramatical changes , while testesterone within testes was reduced dosagedependently and T is significantly depressed( P < 0. 05) at high dosage . The results suggested that Bachmedesh had no effects on FSH and LH, but disturbed the synthesis or secretion of testosterone , which may be one of the possible pathway of Bachmedesh 's toxicity on sperm in male mice. . |
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| Keywords: | Bachmedesh Follicle stimulating hormone Luteinzing hormone Testosterone Mice testes |
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