| 2-羟基-4'-氯查尔酮的合成 |
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| 引用本文： | 尹振晏,李艳云,王帅.2-羟基-4'-氯查尔酮的合成[J].精细化工中间体,2012,42(1):37-39,42. |
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| 作者姓名： | 尹振晏 李艳云 王帅 |
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| 作者单位： | 北京石油化工学院化工系,北京,102617 |
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| 摘 要： | 以邻羟基苯甲醛和对氯苯乙酮为原料,乙醇为溶剂,氢氧化钾为催化剂合成了2-羟基-4'-氯查尔酮。通过正交实验研究了原料配比、反应时间及催化剂浓度对反应的影响。碱性催化合成的优化工艺条件为:原料配比n(邻羟基苯甲醛)∶n(对氯苯乙酮)=1.0∶1.3,反应时间为6.0 h,催化剂氢氧化钾的质量百分比浓度为20%(用量为30 mL)。优化工艺条件下的产品收率96.6%。产品经IR光谱分析、元素分析及熔点测定确证。
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| 关 键 词： | 2-羟基-4'-氯查尔酮 对氯苯乙酮 邻羟基苯甲醛 氢氧化钾催化 |
Synthesis of 2-Hydroxy-4'-chlorochalcone |
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| YIN Zhen-yan
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LI Yan-yun
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WANG Shuai.Synthesis of 2-Hydroxy-4'-chlorochalcone[J].Fine Chemical Intermediates,2012,42(1):37-39,42. |
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| Authors: | YIN Zhen-yan LI Yan-yun WANG Shuai |
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| Affiliation: | (Department of Chemical Engineering,Beijing Institute of Petro-chemical Technology,Beijing 102617,China) |
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| Abstract: | 2-Hydroxy-4’-chlorachalcone was synthesized from p-chloracetophenone and 2-hydroxy benzaldehyde in ethanol catalyzed by potassium hydroxide.Best results with 96.6% yield were obtained under conditions of molar ratio of p-chloracetophenone to 2-hydroxy benzaldehyde of 1 to 1.3,catalyst concentration of 20% and reaction time of 6 h.The product was confirmed with IR spectrum,melting point and elemental analysis. |
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| Keywords: | 2-hydroxy-4’-chlorachalcone p-chloracetopheno 2-hydroxybenzaldehyde potassium hydroxide |
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