| 氯化钯在氟化四丁基铵中当场生成纳米钯：一种高效、可回收的催化体系，在无配体和无溶剂条件下催化Suzuki-Miyaura反应 |
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| 引用本文： | 陶李明,ab 谢叶香,a 邓辰亮,a 李金恒a.氯化钯在氟化四丁基铵中当场生成纳米钯：一种高效、可回收的催化体系，在无配体和无溶剂条件下催化Suzuki-Miyaura反应[J].中国化学,2009,27(7):1365-1373. |
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| 作者姓名： | 陶李明 ab 谢叶香 a 邓辰亮 a 李金恒a |
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| 作者单位： | a湖南师范大学化学生物学与中药分析教育部重点实验室 长沙 410081 ;b 湘南学院化学与生命科学系 郴州 423000 ; |
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| 摘 要： | 氯化钯在氟化四丁基铵中当场生成纳米钯，该钯催化剂在Suzuki-Miyaura交叉偶联反应中显示很高的催化效率。在氯化钯和氟化四丁基铵存在下，许多芳基卤代烃可以顺利与芳基硼酸发生偶联反应，得到中等到高的产率。此外，在Suzuki-Miyaura偶联反应中该氯化钯/氟化四丁基铵催化体系可以回收重复使用多次，并且芳基溴代烃可以在15-60分钟内反应完全。值得指出的是，该反应是在无溶剂、无配体和催化体系可回收重复使用的条件下进行的。这和无配体条件下TBAB中钯催化卤代芳烃与芳基硼酸的Suzuki-Miyaura交叉偶联反应方法。该氯化钯/氟化四丁基铵催化反应的反应机理也进行了讨论。
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| 关 键 词： | 氯化钯 氟化四丁基铵 Suzuki-Miyaura反应 卤代芳烃 芳基苯硼酸 |
| 收稿时间： | 2008-9-25 |
| 修稿时间： | 2008-12-9 |
Generation of Pd Nanoparticles in situ from PdCl2 in TBAF: An Efficient and Reusable Catalytic System for the Suzuki‐Miyaura Reaction under Ligand‐ and Solvent‐free Conditions |
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| Liming TAO,Yexiang XIE,Chenliang DENG,Jinheng LI.Generation of Pd Nanoparticles in situ from PdCl2 in TBAF: An Efficient and Reusable Catalytic System for the Suzuki‐Miyaura Reaction under Ligand‐ and Solvent‐free Conditions[J].Chinese Journal of Chemistry,2009,27(7):1365-1373. |
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| Authors: | Liming TAO Yexiang XIE Chenliang DENG Jinheng LI |
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| Affiliation: | 1. Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha, Hunan 410081, China;2. Department of Chemistry and Life Science, Xiangnan University, Chenzhou, Hunan 423000, China;3. Tel.: 0086‐0731‐8872576;4. Fax: 0086‐0731‐8872101 |
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| Abstract: | Pd nanoparticles were generated in situ from PdCl2 in TBAF (n‐Bu4NF), which displayed high efficiency for the Suzuki‐Miyaura cross‐coupling reaction. In the presence of PdCl2 and TBAF, a variety of aryl halides were coupled with arylboronic acids smoothly in moderate to good yields. Moreover, the PdCl2/TBAF system could be recovered and reused several times in the Suzuki‐Miyaura reaction, and aryl bromides could be consumed completely by arylboronic acids in about 15–60 min. It is noteworthy that these reactions were conducted under solvent‐free, ligand‐free and reusable conditions. Mechanism for the PdCl2/TBAF‐catalyzed reactions was also discussed. |
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| Keywords: | PdCl2 TBAF Pd nanoparticle Suzuki‐Miyaura reaction aryl halide arylboronic acid |
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