| 鹅掌柴属化学成分与药理活性研究进展 |
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| 引用本文： | 王艳,陈若芸,于德泉.鹅掌柴属化学成分与药理活性研究进展[J].中国中药杂志,2013,38(14):2254-2263. |
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| 作者姓名： | 王艳 陈若芸 于德泉 |
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| 作者单位： | 中国医学科学院 北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2012ZX09301002001003) |
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| 摘 要： | 鹅掌柴属Schefflera植物是五加科Araliaceae无刺乔木或灌木,广泛分布于两半球的热带与亚热带区域,在中国主要分布于西南与东南地区。该属中多种植物可以药用,常被用于治疗风湿痹痛、跌打肿痛、骨折、头痛、牙痛、腰痛、脘腹疼痛等多种疼痛。该属植物的化学成分主要是三萜及其皂苷类,除此还有长链化合物、甾体及其苷类、倍半萜、有机酸、苄苷类、单糖及寡糖、木脂素、醌类、二萜等。药理活性主要表现在镇痛抗炎、抗肿瘤、抗菌抗病毒、受体结合活性、抗过敏、抗疟疾等方面。为了更好的开发利用本属药用植物,该文综述了该属植物的化学成分与药理活性的研究进展。
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| 关 键 词： | 鹅掌柴属 三萜 皂苷 镇痛 抗炎 抗肿瘤 |
| 收稿时间： | 4/9/2013 12:00:00 AM |
Advances of chemical constituents and pharmacological activities of Schefflera genus |
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| WANG Yan,CHEN Ruo-yun and YU De-quan.Advances of chemical constituents and pharmacological activities of Schefflera genus[J].China Journal of Chinese Materia Medica,2013,38(14):2254-2263. |
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| Authors: | WANG Yan CHEN Ruo-yun and YU De-quan |
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| Affiliation: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | The genus Schefflera (Araliaceae) consists of 1 100 species, 35 of which can be found in China. Some species of the genus have been used in traditional medicine to treat rheumatalgia, trauma, fracture, headache, and so on. Phytochemical studies of the genus have demonstrated the presence of large number of triterpenoids and their saponins, along with some long-chain compounds, steroids and sesquiterpenes.Furthermore, many pharmacological activities of the genus such as anti-inflammatory, anticancer and antiviral activities have been reported. In this article, new development of constituents and biological activities of Schefflera genus is reviewed and summarized for its further development and utilization. |
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| Keywords: | Schefflera genus triterpenoids saponins anti-inflammatory anticancer |
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