调肾疏肝针法对乳腺增生患者内分泌、免疫功能的影响

目的:探讨针刺治疗乳腺增生病的较佳配穴和作用机制。方法:将200例乳腺增生患者随机分为调肾疏肝针法组(简称调肾疏肝组)、常规针刺组和中药组。调肾疏肝组穴取肾俞、命门、风府、灵墟、神封、步廊、期门等,每日针刺1次;常规针刺组穴取足三里、膻中、肝俞、乳根、内关、期门,治疗方法同调肾疏肝组;中药组口服乳癖消片,每次6片,每日3次。3组患者皆治疗2个月经周期后,观察疗效及雌二醇(E2)、泌乳素(PRL)、孕酮(P)、淋巴细胞亚群CD3 、CD4 、CD8 变化情况。结果:调肾疏肝组临床疗效、中医证候疗效总有效率分别为92.0%、94.0%,常规针刺组分别为86.0%和88.0%,中药组分别为78.0%和84.0%,3组患者疗效比较差异均有统计学意义(P<0.05),调肾疏肝组疗效优于另2组;与治疗前相比,3组患者血清PRL、P、P/E2均有显著改善(P<0.05),调肾疏肝组降低PRL和升高P、P/E2作用优于另2组(P<0.05);与治疗前相比,调肾疏肝组和常规针刺组E2、CD8 、CD4 /CD8 有显著改善,调肾疏肝组降低E2的作用优于常规针刺组(P<0.05)。结论:调肾疏肝针法是治疗乳腺增生病的有效方法,对乳腺增生患者的内分泌、免疫功能有调节作用。

Effects of the needling method for regulating kidney and smoothing liver on endocrine and immunefunctions in the patient with hyperplasia of mammary glands

Objective To probe into a better acupoint association for treatment of hyperplasia of mammary glands and the mechanism.Methods Two hundred cases were randomly divided into a regulating kidney and smoothing liver needling group,a routine acupuncture group and a Chinese medicine group.The regulating kidney and smoothing liver needling group were treated with acupuncture at Shenshu(BL 23),Mingmen(GV 4),Fengfu(GV 16),Lingxu(KI 24),Shenfeng(KI 23),Bulang(KI 22),Qimen(LR 14),etc.and the routine acupuncture group with acupuncture at Zusanli(ST 36),Tanzhong(CV 17),Ganshu(BL 18),Rugen(ST 18),Neiguan(PC 6),Qimen(LR 14),once daily;and the Chinese medicine group with oral administration of Rupixiao tablet,6 tablets each time,thrice each day.After they were treated for 2 menstrual cycles,the therapeutic effects and changes of E2,PRL,P,CD 3,CD 4 and CD 8 were observed.Results The clinical therapeutic effect and the total effective rate for TCM syndromes were 92.0% and 94.0% in the regulating kidney and smoothing liver needling group,86.0% and 88.0% in the routine acupuncture group and 78.0% and 84.0% in the Chinese medicine group,with a significant difference among the 3 groups,the former being better than the other two groups;after treatment,serum PRL,P,P/E2 significantly improved in all the 3 groups(P<0.05) and the regulating kidney and smoothing liver needling group was better than other two groups in decreasing PRL and increasing P,P/E2(P<0.05);and E2,CD 8,CD 4/CD 8 significantly improved in the regulating kidney and smoothing liver needling group and the routine acupuncture group,the former being better than the later in decreasing E2(P<0.05).Conclusion The regulating kidney and smoothing liver needling method is an effective method for treatment of hyperplasia of mammary glands and it has regulative action on endocrine and immune functions in the patient with hyperplasia of mammary glands.