磁共振中央静脉征在多发性硬化方面的作用

多发性硬化的诊断通常比较困难,及时、正确的诊断对疾病的早期治疗和预后有重要的作用。磁共振成像是常规用于检测脑白质病变的较敏感的工具,但其诊断特异性仍不理想,故临床上经常出现诊断不明确的病例。MRI对颅内静脉周围的病灶的检测提高了诊断的特异性,对颅内中央静脉征的发现有望成为诊断的标志物。研究证明,白质病灶中中央静脉征的存在有助于区分多发性硬化和与其类似的炎性疾病及自身免疫性疾病。该文系统分析中央静脉征在头颅磁共振的特征及其在多发性硬化诊断和鉴别方面的作用,为临床提供重要线索。

Value of the central vein sign in multiple sclerosis

The diagnosis of multiple sclerosis(MS) is often difficult, timely and correct diagnosis plays an important role in the early treatment and prognosis of the disease.In multiple sclerosis, magnetic resonance imaging(MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal;ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain(the "central vein sign, CVS") improves the pathological specificity of MS diagnosis, and the discovery of central vein sign is expected to be a marker for the diagnosis of MS. Recent studies have demonstrated that the CVS may have the ability to accurately differentiateMSfrom its mimics. This review will systematically analyze the characteristics of CVS of MRI and its role in the diagnosis and differentiation of MS to provide important clues for the clinical diagnosis of MS.