Multi-step precipitation separation system using mixture of thermosensitive polymers |
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Authors: | Takeshi Mori Hironori Mori Keiji Minagawa Masami Tanaka |
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Affiliation: | (1) Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima, Minamijosanjima-cho, Tokushima 770-8506, Japan;(2) Faculty of Pharmaceutical Science, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan |
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Abstract: | Summary Multi-step precipitation separation system was developed by using aqueous mixtures of some thermosensitive polymers. The following
three polymers were used here; poly(N-n-propylacrylamide), poly(N-isopropylacrylamide), and poly(N-isopropylmethacrylamide). A mixture of the three polymers showed three endothermic peaks, and the peak top temperatures were
almost consistent with that of the each polymer solution. The polymers were purified by thermal precipitation to obtain fractions
which can respond in narrow temperature ranges prior to use. In the case of the precipitation separation of two polymers mixtures,
purities of the obtained precipitate and supernatant fractions became high comparing with the case in which the unpurified
polymers were used. Parts of the polymers which were not the precipitation targets were also precipitated by the separation
procedures. This was caused not only by insolubilization of the non-targeted polymers due to their phase transitions but also
by their non-specific entanglement with the targeted polymers. The purities of the fractions also improved when the difference
of the phase transition temperature between two polymers was large enough to avoid the coprecipitation. In the case of the
precipitation separation of mixtures of the three polymers, purities of each fraction also improved when the purified polymers
were used. |
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