| 稳心颗粒对心肌梗死大鼠血管内皮细胞超微结构的影响 |
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| 引用本文： | 关信民,蒙荣森,陈思伟,金伟,漆蝉,裴兆辉,马虹.稳心颗粒对心肌梗死大鼠血管内皮细胞超微结构的影响[J].医疗保健器具,2011(2):191-192. |
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| 作者姓名： | 关信民 蒙荣森 陈思伟 金伟 漆蝉 裴兆辉 马虹 |
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| 作者单位： | 广州市红十字会医院心内科;中山大学附属第一医院心内科;南昌市第三医院心内科; |
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| 摘 要： | 目的观察稳心颗粒对心肌梗死大鼠内皮细胞超微结构的影响。方法将30只SD大鼠随机分为对照组，心肌梗死模型组，心肌梗死模型＋稳心颗粒组，每组10只大鼠。测定大鼠血浆NO及ET一1含量变化．观察血管内皮细胞超微结构的改变。结果与对照组比较，心肌梗死模型组大鼠血浆ET-1含量明显增加（P〈0，01），血浆NO含量明显减少（P〈O．01），线粒体肿胀，肌浆网扩张，内皮脱落。与心肌梗死模型组比较，心肌梗死模型＋稳心颗粒组大鼠血浆ET一1的含量明显降低（p〈O．01），血浆NO的含量明显增加（p〈0．01），内皮细胞出现线粒体肿胀和内质网扩张明显减少，无内皮脱落。结论稳心颗粒对心肌梗死大鼠血管内皮细胞超微结构具有保护作用，这种保护作用与稳心颗粒使NO及ET-1的含量发生变化有关。
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| 关 键 词： | 稳心颗粒 超微结构 NO ET-1 |
Effects of Wenxinkeli on the Ultrastructure of Vascular Endothelia Cells in Rats with Myocardial Infarction |
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| GUAN Xinmin,MENG Rongsen,CHEN Siwei,JIN Wei,QI Chan,PEI Zhaohui,MA Hong.Effects of Wenxinkeli on the Ultrastructure of Vascular Endothelia Cells in Rats with Myocardial Infarction[J].Medicine Healthcare Apparatus,2011(2):191-192. |
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| Authors: | GUAN Xinmin MENG Rongsen CHEN Siwei JIN Wei QI Chan PEI Zhaohui MA Hong |
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| Affiliation: | GUAN Xinmin1,MENG Rongsen1,3,CHEN Siwei1,JIN Wei2,QI Chan2,PEI Zhaohui2,MA Hong3(1Department of Cardiology,Red Cross Hospital of Guangzhou,Guangzhou 510220,China,2Department of Cardiology,the Third Hospital of Nanchang,Nanchang 330009,3Department of Cardiology,the First Affiliated Hospital of SUN YAT-Sen University,Guangzhou 510080,China) |
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| Abstract: | Objective To observe the effects of Wenxinkeli on the ultrastructure of vascular endothelia cells in rats with myocardial infarction(MI).Methods 30 SD rats were divided randomly into control group(n=10),MI group(n=10) and MI + Wenxinkeli group(n=10).The contents of nitric oxide(NO) and endothelin-1(ET-1) were detected in plasma of rats.The ultrastructure of vascular endothelia cells was observed by electron microscope.Results Compared with control group,the content of NO significantly decreased(P <0.01) and... |
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| Keywords: | Wenxinkeli Ultrastructure NO ET-1 |
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