| 汉族、哈萨克族Graves病患者血清CoL IV、LN和HA测定分析 |
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| 引用本文： | 周志芬,崔新河,刘茹珍.汉族、哈萨克族Graves病患者血清CoL IV、LN和HA测定分析[J].农垦医学,1996(3). |
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| 作者姓名： | 周志芬 崔新河 刘茹珍 |
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| 作者单位： | 伊犁州奎屯医院 |
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| 摘 要： | 用放免法(单克隆抗体)测定汉、哈萨克族Graves病未经治疗患者66例及正常对照组55例血清中Ⅳ型胶原(CoLⅣ)、板层素(IN)和透明质酸(HA),结果Graves病患者血清CoLⅣ、LN浓度明显升高,HA浓度明显降低,与正常对照组相比均有显著性差异(分别P<0.001、P<0.05、P<0.05),汉族与哈萨克族患者之间、对照组之间相比均无显著性差异(P>0.05),它反映了Graves病患者体内基底膜合成和分解代谢紊乱。
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| 关 键 词： | Graves病 Ⅳ型胶原 板层素 透明质酸 汉族 哈萨克族 |
THE DETERMINATION AND ANALYZATION OF SURUM TYPE IV COLLAGEN (COL IV). LAMININ(LN). HYALURONIC ACID (HA) IN PATIENTS WITH GRAVES DISEASE (GD) IN HAN AND HASAKE NATIONALITY |
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| Zhou Zhi fen et al Kui Tun hospital,Yi Li Zhous Xin Jiang.THE DETERMINATION AND ANALYZATION OF SURUM TYPE IV COLLAGEN (COL IV). LAMININ(LN). HYALURONIC ACID (HA) IN PATIENTS WITH GRAVES DISEASE (GD) IN HAN AND HASAKE NATIONALITY[J].Agricultural Reclamation Medicine,1996(3). |
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| Authors: | Zhou Zhi fen Kui Tun hospital Yi Li Zhous Xin Jiang |
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| Abstract: | Serum Concentrations of type IV collagen (CoL IV) ,laminin(LN) ,hyaluronic acid (HA) were determined ty RIA (monoclone antibody) in 66 patients with untreated Graves disease (GD) and 55 healthy subjects in Han nationality and Hasake nationality.Serum Col IV. LN were significantly higher (p<0. 001,P<0. 05 respectively) and HA was significantly lower (p<0. 05) in GD than in the healthy subjects . No difference in serum concentrations of CoL IV. LN and HA were observed between Han and Hasake nationality either in the patients with GD or in the healthy subject. The result proposed the disorder of synthesis and degradation metabolism of basement membrane in GD. |
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| Keywords: | Graves disease Type Iv collagen Laminin Hyaluronic acid Han nationality Hasake nationlity |
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