| 肿瘤免疫检查点抑制剂相关的肝毒性 |
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| 引用本文： | 雷晓红,唐颖悦,李静,茅益民.肿瘤免疫检查点抑制剂相关的肝毒性[J].中华肝脏病杂志,2020(2):175-178. |
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| 作者姓名： | 雷晓红 唐颖悦 李静 茅益民 |
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| 作者单位： | 上海交通大学医学院附属仁济医院消化内科 |
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| 基金项目： | “十三五”科技重大专项(2017ZX09304016);国家自然科学基金课题(81670524);上海交通大学医学院多中心临床研究项目(DLY201607);上海申康医院发展中心临床创新三年行动计划项目(16CR2009A)。 |
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| 摘 要： | 肿瘤免疫检查点抑制剂治疗为肿瘤患者带来生存获益的同时,也面临了许多挑战,例如免疫介导的肝毒性的发生。深入了解免疫检查点抑制剂治疗肿瘤过程中导致肝损伤的发生情况、可能机制、危险因素等,有助于更好地临床管理。
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| 关 键 词： | 肿瘤 自身免疫性 免疫检查点抑制剂 肝毒性 |
Hepatotoxicity associated with tumor immune checkpoint inhibitors |
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| Lei Xiaohong,Tang Yingyue,Li Jing,Mao Yimin.Hepatotoxicity associated with tumor immune checkpoint inhibitors[J].Chinese Journal of Hepatology,2020(2):175-178. |
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| Authors: | Lei Xiaohong Tang Yingyue Li Jing Mao Yimin |
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| Affiliation: | (Division of Gastroenterology and Hepatology,Key Laboratory of Gastroenterology and Hepatology,Ministry of Health,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Institute of Digestive Disease,Shanghai 200001,China) |
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| Abstract: | Although tumor immune checkpoint inhibitors therapy brings survival benefits to cancer patients,it also faces many challenges,such as the occurrence of immune-mediated hepatotoxicity.Therefore,an in-depth understanding of the conditions,possible mechanisms,and risk factors that cause liver injury during the treatment of tumor immune checkpoint inhibitors will facilitate better clinical management. |
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| Keywords: | Neoplasms Autoimmune Immunological checkpoint inhibitors Hepatotoxicity |
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