普瑞巴林和消炎痛治疗带状疱疹后神经痛的效果比较

目的探讨普瑞巴林在治疗带状疱疹后神经痛的临床疗效。方法回顾性分析在我院进行治疗的带状疱疹后神经痛患者60例的临床资料，其中采用普瑞巴林治疗的患者30例，采用消炎痛治疗的患者30例，比较两组治疗前和治疗后不同时间点疼痛程度、生活质量、持续睡眠时间、疼痛问卷简表分值的改变、不良反应等。结果两组治疗前后VAS评分均有显著好转。但普瑞巴林组疼痛评分下降更明显（P〈0．01）。两组治疗前后持续睡眠情况均显著好转，但普瑞巴林组好转更明显（P〈0．01）。普瑞巴林组治疗前后生活质量有显著改善，治疗4周后各维度与消炎痛组比较，差异有统计学意义（P〈0．05或〈0．01）。普瑞巴林组治疗前后SF—MPQ分值显著下降（P〈0．01），治疗4周后与消炎痛组比较，差异有统计学意义（P〈0．01）。消炎痛组眩晕、腹痛、恶心呕吐的发病率均显著高于普瑞巴林组（P〈0．05或〈0．01）。结论普瑞巴林治疗带状疱疹后神经痛疗效好、副作用少。能显著改善患者的生活质量和睡眠质量。

Comparison of effect between pregabalin and indometacin for postherpetic neuralgia

Objective To discuss effect between pregabalin and indometacin for postherpetic neuralgia. Methods Retrospective analyzed clinical data of 60 cases with postherpetic neuralgia. 30 cases were treated by pregabalin, and 30 cases were treated by indometacin. The different time points before and after treatment, the pain degree of quality of life changes in sleep duration, pain questionnaire score summary table adverse reactions of two groups were compared. Results Two groups of VAS scores before and after the treatment were significantly improved, but pregabalin group pain score decreased more significantly （P 〈 0.01）. In the two groups before and after treatment for sleep duration were significantly improved, but pregabalin group improved more significantly （P 〈 0.01）. Pregabalin group of the quality of life before and after the treatment was improved, after treatment for 4 weeks every dimension compared with indomethacin group was statistically significant （P 〈 0.05 or 〈 0.01）. Pregabalin group of SF - MPQ scores before and after the treatment was decreased significantly （P 〈 0.01）, 4 weeks after treatment compared with indomethacin group, the difference was statistically significant （P 〈 0.01）. The incidence of dizziness, abdominal pain, nausea and vomiting indomethacin group, were significantly higher than pregabalin group （P 〈 0.05 or 〈 0.01）. Conclusion Pregabalin for treatment of postherpetic neuralgia shows good efficacy with less complications, and can improve quality of life and sleep quality.