| 高血糖症对大鼠血管内皮舒张功能的影响 |
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| 引用本文： | 段文卓,唐朝枢.高血糖症对大鼠血管内皮舒张功能的影响[J].中国病理生理杂志,1998,14(5):488-490. |
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| 作者姓名： | 段文卓 唐朝枢 |
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| 作者单位： | 潍坊医学院病理生理教研室，北京医科大学心血管基础研究所 |
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| 摘 要： | 目的：复制高血糖症动物模型，研究高糖对大鼠血管内皮舒张功能的影响及其机制。方法：采用血管功能检测、组织培养及放射免疫分析方法。结果：①高血糖组血管乙酰胆硷依赖性血管舒张反应明显降低（Ｐ＜００１）；②高血糖组血浆ＮＯ－２含量、主动脉一氧化氮合成酶（ＮＯＳ）活性及环磷酸鸟苷（ｃＧＭＰ）含量明显低于对照组（Ｐ＜００５，Ｐ＜００１）。结论：长期高血糖症可引起血管内皮源性血管舒张因子／一氧化氮（ＥＤＲＦ／ＮＯ）系统出现严重障碍，从而降低了血管舒张功能
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| 关 键 词： | 高血糖症 一氧化氮 内皮，血管 血管舒张 |
Effect of hyperglycemia on vascular endothelium-dependent relaxation in rats |
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| DUAN Wen-Zhuo,WANG Jia-Fu,DING Yi,SONG Xiu-Yuan,LIU Tong-Mei,WANG Jian-Ying,HOU Jian-Ping,GONG Hai-Min,TANG Chao-Shu,LI Xia.Effect of hyperglycemia on vascular endothelium-dependent relaxation in rats[J].Chinese Journal of Pathophysiology,1998,14(5):488-490. |
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| Authors: | DUAN Wen-Zhuo WANG Jia-Fu DING Yi SONG Xiu-Yuan LIU Tong-Mei WANG Jian-Ying HOU Jian-Ping GONG Hai-Min TANG Chao-Shu LI Xia |
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| Abstract: | AIM:To make hyperglycemia models to observe the effects of hyperglycemia on vascular endothelium relaxative function in rats.METHODS:Used vascular function detection,tissue culture and radioactivity analysis.RESULTS:NO - 2 content,NOS activity and vasodilatory response in hyperglycemia group was lower than control group.CONCLUSION:It was possible that hyperglycemia reduced vasodilatory function by inducing a disturbance of endothelium endothelium-derived relaxing factor /NO system. |
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| Keywords: | Hyperglycemia Nitric oxide Endothelium vascular Vasodilation |
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