Disturbance of hepatic and intestinal microcirculation in experimental liver cirrhosis |
| |
Authors: | Maksan Sasa-Marcel Ryschich Eduard Ulger Zilfi Gebhard Martha Maria Schmidt Jan |
| |
Affiliation: | 1. Department of Surgery, University of Mainz,Germany 2. Department of Surgery, University of Heidelberg,Germany |
| |
Abstract: | AIM: To analyze hepatic, mesenteric and mucosal microcirculation and leukocyte-endothelium interaction (LEI) in a rat model with liver cirrhosis. METHODS: Hepatic cirrhosis was induced in Wistar rats by gavage with carbon tetrachloride, and intravital videomicroscopy was performed in liver, mesentery and small intestine mucosa. Special emphasis is given on microcirculatory and morphometric changes during cirrhotic portal hypertension. RESULTS: LEI was influenced significantly in the cirrhotic liver but not in the gut. Blood flow measurement showed significant differences among liver, main mesenteric vessels and the mucosa. The results of our study indicate that liver cirrhosis leads to alterations in hepatic and mesenteric blood flow but not in mucosal blood flow. CONCLUSION: The enhanced inflammatory response in hepatic microvessels may be caused by a decrease of antithrombin III levels and could be responsible for disturbances of organ pathology. |
| |
Keywords: | Liver cirrhosis Microcirculation Small intestine Liver |
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录! |